ArticleHypertension (Dallas, Tex. : 1979)2021
Targeting MicroRNA-192-5p, a Downstream Effector of NOXs (NADPH Oxidases), Reverses Endothelial DHFR (Dihydrofolate Reductase) Deficiency to Attenuate Abdominal Aortic Aneurysm Formation.
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Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- The emerging molecular landscape of abdominal aortic aneurysms: non-coding RNAs as diagnostic and therapeutic targets.Molecular biology reports · 2026Review
- Mechanotransduction through oxidative stress upregulates circLyst to drive vascular remodeling in hypertensive humans and rodents.Molecular biomedicine · 2026Article
- Oxidative stress-induced endothelial dysfunction drives mechanical and infectious lung injury: Therapeutic potential of kaempferol in males.Redox biology · 2026Article
- Mechanosensitive reactive oxygen Species:A precision medicine target for oxidative stress-related diseases.Mechanobiology in medicine · 2026Article
- Endothelial NOX1 Drives Obesity via Skeletal Muscle Mitochondrial Dysfunction.Circulation research · 2026Article
- Antioxidation is a Common Defense Strategy for Different Species Under Mechanical Stress.Advanced genetics (Hoboken, N.J.) · 2026Article
- Article
- A Bibliometric Analysis of P2X7R in Cardiovascular Diseases from 2005 to 2024.Current cardiology reviews · 2026Review
- Attenuation of advanced atherosclerosis and aortic aneurysm in hph-1/apoE DKO mice by folic acid and DHFR overexpression.Frontiers in physiology · 2026Article
- Targeting vascular inflammation and endothelial dysfunction with nanobodies: emerging therapeutic strategies for cardiovascular disease.Frontiers in immunology · 2026Review
- Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator-Induced Lung Injury: Potential Treatment with Quercetin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Injury and cyclic stretch induce vein graft failure: effective treatment with zinc oxide-loaded electrospun polycaprolactone external stent.Regenerative biomaterials · 2025Article
- miRNA in mechanobiology: The exploration needs to continue.Mechanobiology in medicine · 2024Article
- Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR.Circulation research · 2024Article
- Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication.Redox biology · 2022Article
- Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms.Redox biology · 2022Article
- Robust therapeutic effects on COVID-19 of novel small molecules: Alleviation of SARS-CoV-2 S protein induction of ACE2/TMPRSS2, NOX2/ROS, and MCP-1.Frontiers in cardiovascular medicine · 2022Article
- Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial CellsFrontiers in pharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Kai Huang *Division of Molecular Medicine, Department of Anesthesiology (K.H., T.N., Y.Z., Q.L., P.M., Y.W., N.M.L., H.C.), David Geffen School of Medicine, University of California Los Angeles.
Taro Narumi *Division of Molecular Medicine, Department of Anesthesiology (K.H., T.N., Y.Z., Q.L., P.M., Y.W., N.M.L., H.C.), David Geffen School of Medicine, University of California Los Angeles.
Yixuan ZhangDivision of Molecular Medicine, Department of Anesthesiology (K.H., T.N., Y.Z., Q.L., P.M., Y.W., N.M.L., H.C.), David Geffen School of Medicine, University of California Los Angeles.
Qiang LiDivision of Molecular Medicine, Department of Anesthesiology (K.H., T.N., Y.Z., Q.L., P.M., Y.W., N.M.L., H.C.), David Geffen School of Medicine, University of California Los Angeles.
Priya MurugesanDivision of Molecular Medicine, Department of Anesthesiology (K.H., T.N., Y.Z., Q.L., P.M., Y.W., N.M.L., H.C.), David Geffen School of Medicine, University of California Los Angeles.
Yusi WuDivision of Molecular Medicine, Department of Anesthesiology (K.H., T.N., Y.Z., Q.L., P.M., Y.W., N.M.L., H.C.), David Geffen School of Medicine, University of California Los Angeles.
Norika Mengchia LiuDivision of Molecular Medicine, Department of Anesthesiology (K.H., T.N., Y.Z., Q.L., P.M., Y.W., N.M.L., H.C.), David Geffen School of Medicine, University of California Los Angeles.
Hua CaiDivision of Molecular Medicine, Department of Anesthesiology (K.H., T.N., Y.Z., Q.L., P.M., Y.W., N.M.L., H.C.), David Geffen School of Medicine, University of California Los Angeles.
University of California, Los Angeles · US
Funding
Angiotensin II Uncoupling of Enos in HypertensionR01HL077440 · NHLBI · UNIVERSITY OF CHICAGO · PI CAI, HUA LINDA · 2005 to 2019
$4.8MNOXs, eNOS Uncoupling and Diabetic AtherogenesisR01HL088975 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2010 to 2019
$4.5MTargeting NOX4-dependent mitochondrial dysfunction, autophagy and defective calcium handling in AFR01HL162407 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, GOLDHABER, JOSHUA I · 2022 to 2025
$2.8MPhenotypes and mechanisms of pulmonary hypertension-driven cognitive impairment and Alzheimer's diseaseR01HL154754 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, MAKINO, AYAKO · 2020 to 2023
$2.5MNetrin-1 and Netrin-1 Preconditioned EPCs in Vascular ProtectionR01HL142951 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2020 to 2023
$2.0MNHLBI NIH HHS R01 HL077440NHLBI NIH HHS R01 HL088975NHLBI NIH HHS R01 HL142951NHLBI NIH HHS R01 HL154754NHLBI NIH HHS R01 HL162407
Abstract
[Figure: see text].
Indexed as
AgedAged, 80 and overAortaAortic Aneurysm, AbdominalDown-RegulationEndothelial CellsEndothelium, VascularFemaleHumansHydrogen PeroxideMaleMicroRNAsMiddle AgedNADPH OxidasesNitric OxideNitric Oxide Synthase Type IIIHydrogen PeroxideMicroRNAsMIRN192 microRNA, humanNADPH OxidasesNitric OxideNitric Oxide Synthase Type IIITetrahydrofolate Dehydrogenaseangiotensin IIaortic aneurysm, abdominaldihydrofolate reductaseendothelial nitric oxide synthasemicroRNANADPH oxidaseoxidative stress
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.