Evidence map›Paper›PMID 34176234›Full record

Trial reportJournal of diabetes investigation2022

Effects of intermittent very-low calorie diet on glycemic control and cardiovascular risk factors in obese patients with type 2 diabetes mellitus: A randomized controlled trial.

Mongkontida Umphonsathien, Peedaporn Rattanasian, Siriporn Lokattachariya, Wanlapa Suansawang, Kunwadee Boonyasuppayakorn, Weerapan Khovidhunkit

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 6 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mongkontida UmphonsathienDivision of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, and Hormonal and Metabolic Disorders Research Unit, Chulalongkorn University and Excellence Center in Diabetes, Hormone and Metabolism, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.ORCID https://orcid.org/0000-0003-1558-147X
Peedaporn RattanasianDepartment of Dietetic and Diet Therapy, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Siriporn LokattachariyaDepartment of Dietetic and Diet Therapy, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Wanlapa SuansawangDepartment of Dietetic and Diet Therapy, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Kunwadee BoonyasuppayakornDepartment of Dietetic and Diet Therapy, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Weerapan KhovidhunkitDivision of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, and Hormonal and Metabolic Disorders Research Unit, Chulalongkorn University and Excellence Center in Diabetes, Hormone and Metabolism, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.ORCID https://orcid.org/0000-0003-4511-416X
Thai Red Cross Society · TH

Funding

Heath Systems Research Institute (HRSI)National Research Council of ThailandRoche®Thai Otsuka Pharmaceutical®
6 · The paper itself

Abstract

AIMS/

introductionVery few studies assess the effectiveness of different protocols of intermittent very-low calorie diet (VLCD) in patients with diabetes. This study was designed to compare the effects of 2 days/week and 4 days/week of intermittent VLCD on glycemic control, diabetes remission, metabolic parameters and quality of life in patients with type 2 diabetes and obesity. MATERIALS AND

methodsParticipants with obesity and type 2 diabetes were recruited and randomly assigned to three groups, consisting of control, 2 days/week and 4 days/week of intermittent VLCD. In the intermittent VLCD groups, participants received a 600-kcal diet per day on restricted days and ad libitum food consumption on non-restricted days. Glycemic control, rate of diabetes remission, metabolic parameters and quality of life were evaluated at baseline, weeks 2, 10 and 20.

resultsA total of 40 participants were enrolled. The mean body mass index was 30.1 ± 5.9 kg/m

conclusionIntermittent VLCD was highly effective in achieving optimal glycemic control. The effects of 2 days/week and 4 days/week of intermittent VLCD on diabetes remission were relatively similar.

Indexed as

AdultCaloric RestrictionDiabetes Mellitus, Type 2FemaleGlycemic ControlHeart Disease Risk FactorsHumansMaleMiddle AgedObesityRemission InductionTreatment OutcomeDiabetesIntermittent very-low calorie dietObesity

Identifiers

PMID34176234
PMCPMC8756303
OpenAlexW3175010516

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.