ArticleEuropean journal of neurology2021
Bruns' nystagmus revisited: A sign of stroke in patients with the acute vestibular syndrome.
Article in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Accuracy of First-Line Tests for Posterior Circulation Stroke in the Emergency Department: A Scoping Review.Cureus · 2025Review
- Spontaneous Nystagmus Violating the Alexander's Law: Neural Substrates and Mechanisms.Cerebellum (London, England) · 2025Article
- Nystagmus in Clinical Practice: From Diagnosis to Treatment-A Comprehensive Review.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Clinical Assessment of the Nystagmus Fixation Suppression Test: An Experimental Study.The journal of international advanced otology · 2024Article
- Quantifying Induced Nystagmus Using a Smartphone Eye Tracking Application (EyePhone).Journal of the American Heart Association · 2024Article
- Digital biomarkers from gaze tests for classification of central and peripheral lesions in acute vestibular syndrome.Frontiers in neurology · 2024Article
- Do monosymptomatic stroke patients with dizziness present a vestibular syndrome without nystagmus? An underestimated entity.European journal of neurology · 2024Article
- Article
- Current concepts in acute vestibular syndrome and video-oculography.Current opinion in neurology · 2022Review
- Artificial intelligence for early stroke diagnosis in acute vestibular syndrome.Frontiers in neurology · 2022Article
- Positive horizontal-canal head impulse test is not a benign sign for acute vestibular syndrome with hearing loss.Frontiers in neurology · 2022Article
- Videooculography "HINTS" in Acute Vestibular Syndrome: A Prospective Study.Frontiers in neurology · 2022Article
- Acute unilateral vestibulopathy/vestibular neuritis: Diagnostic criteria.Journal of vestibular research : equilibrium & orientation · 2022Article
- Bruns' nystagmus revisited: A sign of stroke in patients with the acute vestibular syndrome.European journal of neurology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGaze-evoked nystagmus (GEN) is a central sign in patients with the acute vestibular syndrome (AVS); however, discriminating between a pathological and a physiologic GEN is a challenge. Here we evaluate GEN in patients with AVS.
methodsIn this prospective cross-sectional study, we used video-oculography (VOG) to compare GEN in the light (target at 15° eccentric) in 64 healthy subjects with 47 patients seen in the emergency department (ED) who had AVS; 35 with vestibular neuritis and 12 with stroke. All patients with an initial non-diagnostic MRI received a confirmatory, delayed MRI as a reference standard in detecting stroke.
resultsHealthy subjects with GEN had a time constant of centripetal drift >18 s. VOG identified pathologic GEN (time constant ≤ 18 s) in 33% of patients with vestibular strokes, specificity was 100%, accuracy was 83%. Results were equivalent to examination by a clinical expert. As expected, since all patients with GEN had a SN in straight-ahead position, they showed the pattern of a Bruns' nystagmus.
conclusionsOne third of patients with AVS due to central vestibular strokes had a spontaneous SN in straight-ahead gaze and a pathological GEN, producing the pattern of a Bruns' nystagmus with a shift of the null position. The localization of the side of the lesion based on the null was not consistent, presumably because the circuits underlying gaze-holding are widespread in the brainstem and cerebellum. Nevertheless, automated quantification of GEN with VOG was specific, and accurately identified patients in the ED with AVS due to strokes.
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