Evidence map›Paper›PMID 34176100›Full record

ArticleCell biochemistry and biophysics2021

Hyperoxia-induced S1P

Tara Sudhadevi, Anjum Jafri, Alison W Ha, Prathima Basa, Jaya M Thomas, Panfeng Fu, Kishore Wary, Dolly Mehta, Viswanathan Natarajan, Anantha Harijith

Open access · greenAbstract read
In one paragraph

Article in Cell biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. [Expression and regulatory mechanism of miR-34a in neonatal rat model of bron-chopulmonary dysplasia induced by hyperoxia].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
    Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tara SudhadeviDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Anjum JafriDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Alison W HaDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Prathima BasaDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Jaya M ThomasDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Panfeng FuDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Kishore WaryDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Dolly MehtaDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Viswanathan NatarajanDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Anantha HarijithDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA. axh775@case.edu.ORCID http://orcid.org/0000-0002-4868-3862
Case Western Reserve University · USUniversity of Illinois Chicago · US

Funding

Role of novel SphK1 inhibitor, PF543 in therapy of Bronchopulmonary dysplasia and Airway remodelingR01HD090887 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HARIJITH, ANANTHA · 2018 to 2022
$1.5M
American Heart Association 18TPA34230095Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD090887NICHD NIH HHS R01 HD090887
6 · The paper itself

Abstract

introductionWe have earlier shown that hyperoxia (HO)-induced sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) signaling contribute to bronchopulmonary dysplasia (BPD). S1P acts through G protein-coupled receptors, S1P

methodsS1pr1

resultsHO increased the expression of S1pr1 gene as well as S1P

conclusionHO induces S1P

Indexed as

Animals, NewbornBronchopulmonary DysplasiaHyperoxiaReceptor, TIE-2Signal TransductionSphingosine-1-Phosphate ReceptorsAngiogenesisAnimalsDisease Models, AnimalEndothelial CellsHumansLungLysophospholipidsMiceMice, Inbred C57BLNeovascularization, PhysiologicLysophospholipidsReceptors, LysosphingolipidReceptor, TIE-2S1pr1 protein, mouseSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate ReceptorsAngiogenesis.Neonatal lung diseaseOxidative stressSphingosine 1 phosphate receptor

Identifiers

PMID34176100
PMCPMC8551021
OpenAlexW3176089194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.