Evidence map›Paper›PMID 34176086›Full record

SynthesisAging clinical and experimental research2022

Inflammatory markers in postoperative cognitive dysfunction for patients undergoing total hip arthroplasty: a meta-analysis.

Chunmei Fu, Jincheng Lin, Guoliang Gong, Weibin Zhong, Haihong Chen, Xiaowei Luo

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chunmei FuDepartment of Anesthesiology, Chaonan Minsheng Hospital of Shantou, National Highway 324, Xiashan Liannan Town, Chaonan District, Shantou, 515100, China.
Jincheng LinDepartment of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Chuangdong, Shantou, 515041, China.
Guoliang GongDepartment of Pathology, Chaonan Minsheng Hospital of Shantou, National Highway 324, Xiashan Liannan Town, Chaonan District, Shantou, 515100, China. blkggl@163.com.
Weibin ZhongDepartment of Anesthesiology, Chaonan Minsheng Hospital of Shantou, National Highway 324, Xiashan Liannan Town, Chaonan District, Shantou, 515100, China.
Haihong ChenDepartment of Anesthesiology, Chaonan Minsheng Hospital of Shantou, National Highway 324, Xiashan Liannan Town, Chaonan District, Shantou, 515100, China.
Xiaowei LuoDepartment of Pathology, The First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Chuangdong, Shantou, 515041, China.
Shantou University · CN

Funding

Shantou Science and Technology Plan Project Shanfuke【2018】1-15
6 · The paper itself

Abstract

backgroundPostoperative cognitive dysfunction (POCD) is a poorly understood disorder, very common even after total hip arthroplasty (THA). It is widely considered that inflammation response play a role in the pathogenesis of POCD.

aimsThe aim of the present study was to investigate whether inflammation cytokine concentrations could serve as biomarkers for POCD in patients undergoing THA.

methodsA systematic search of databases was conducted to retrieve publications measuring circulating inflammatory markers of patients with and without POCD after THA. Inflammatory markers identified in more than two studies were pooled. The standardized mean difference (SMD) and the 95% confidence interval (95% CI) were calculated for each outcome. Fail-safe N statistics was calculated to estimate possible publication bias.

resultsThe pooled incidence rate of POCD after THA by combining 11 cohort studies was 31%. A total of five inflammatory markers, CRP, S-100B, IL-1β, IL-6 and TNF-α, were assessed. Significantly higher pre-operative CRP (P = 0.012) and S-100B (P < 0.0001) as well as post-operative CPR (P = 0.005) and IL-6 (P < 0.0001) at 6 h were found in POCD compared with non-POCD patients undergoing THA. Fail-safe N statistics revealed that these results are robust. DISCUSSION: The current evidence suggests that some of the inflammatory markers, including CRP, S-100B, and IL-6, were correlated with the occurrence of POCD after THA.

conclusionMonitor of inflammatory markers might help early diagnosis of POCD after THA and development of preventive strategies.

Indexed as

Arthroplasty, Replacement, HipCognitive DysfunctionPostoperative Cognitive ComplicationsBiomarkersHumansPostoperative ComplicationsPostoperative PeriodBiomarkersBiomarkerCognitive dysfunctionCytokineInflammationTotal hip arthroplasty

Identifiers

PMID34176086
OpenAlexW3174536950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.