ArticleMetabolomics : Official journal of the Metabolomic Society2021
Plasma lipid biomarkers in relation to BMI, lung function, and airway inflammation in pediatric asthma.
Article in Metabolomics : Official journal of the Metabolomic Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Umbilical Cord Blood Biomarkers for Early Risk Stratification of Childhood Asthma and Atopic Dermatitis: A Developmental and Critical Appraisal.Journal of asthma and allergy · 2026Review
- Review
- The relationship of fish oil supplements and plasma fatty acids with lung function decline.European journal of nutrition · 2025Article
- The re-emerging role of linoleic acid in paediatric asthma.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Metabolomics Applied to Pediatric Asthma: What Have We Learnt in the Past 10 Years?Children (Basel, Switzerland) · 2023Article
- Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review.Metabolites · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThere is limited understanding of how plasma fatty acid levels affect pulmonary function in pediatric years. It has been speculated that polyunsaturated fatty acids influence asthma via anti or pro-inflammatory mechanisms. Metabolomics presents a new and promising resource for identifying molecular processes involved in asthma pathology.
objectivesWe investigated the relationship of plasma fatty acid metabolites as biomarkers of the 'mild-asthma' phenotype and lung function including airway inflammation in children.
methodsThis cross-sectional study involved 64 children (5-12 years, 33 male) with mild-asthma phenotype attending an outpatient pediatric clinic in Athens, Greece. Clinical examination included spirometry (FVC, FEV
resultsTargeted GC-MS identified 25 unique plasma fatty acids in mild-asthmatic children. Linear regression revealed significant associations between linoleic, oleic, erucic, cis-11-eicosenoic, arachidic acids and FEV
conclusionMetabolomics is a novel science that is useful to discover metabolic signatures specific to disease. Evaluation of fatty acid status could assist clinicians in decision-making about a dietary modification that can be used for personalized nutrition therapies to achieve better asthma control, optimum lung function, and therapeutic response in children.
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Registered trials
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