Evidence map›Paper›PMID 34175982›Full record

ArticlePsychopharmacology2021

Memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine D2 receptor antagonists.

Michael Wolter, Thomas Lapointe, Brett Melanson, Nana Baidoo, Travis Francis, Boyer D Winters, Francesco Leri

Abstract read
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In one paragraph

Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. The anxiogenic drug yohimbine is a reinforcer in male and female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michael WolterDepartment of Psychology, Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.
Thomas LapointeDepartment of Psychology, Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.
Brett MelansonDepartment of Psychology, Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.
Nana BaidooDepartment of Psychology, Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.
Travis FrancisDepartment of Psychology, Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.
Boyer D WintersDepartment of Psychology, Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.
Francesco LeriDepartment of Psychology, Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada. fleri@uoguelph.ca.ORCID http://orcid.org/0000-0003-2700-0812
University of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is evidence that post-training exposure to nicotine, cocaine, and their conditioned stimuli (CS), enhance memory consolidation in rats. The present study assessed the effects of blocking noradrenergic and dopaminergic receptors on nicotine and cocaine unconditioned and conditioned memory modulation.

methodsMales Sprague-Dawley rats tested on the spontaneous object recognition task received post-sample exposure to 0.4 mg/kg nicotine, 20 mg/kg cocaine, or their CSs, in combination with 5-10 mg/kg propranolol (PRO; beta-adrenergic antagonist) or 0.2-0.6 mg/kg pimozide (PIM; dopamine D2 receptor antagonist). The CSs were established by confining rats in a chamber (the CS +) after injections of 0.4 mg/kg nicotine, or 20 mg/kg cocaine, for 2 h and in another chamber (the CS -) after injections of vehicle, repeated over 10 days (5 drug/CS + and 5 vehicle/CS - pairings in total). Object memory was tested 72 h post sample in drug-free animals.

resultsCo-administration of PRO or PIM blocked the memory-enhancing effects of post-training injections of nicotine, cocaine, and, importantly, exposure to their CSs.

conclusionsThese data suggest that nicotine, cocaine as well as their conditioned stimuli share actions on overlapping noradrenergic and dopaminergic systems to modulate memory consolidation.

Indexed as

CocaineAdrenergic AgentsAnimalsDopamine D2 Receptor AntagonistsMaleNicotineRatsRats, Sprague-DawleyAdrenergic AgentsCocaineDopamine D2 Receptor AntagonistsNicotineCocaineConditioned stimulusMemory consolidationNicotineObject recognitionPimozidePropranolol

Identifiers

PMID34175982
OpenAlexW3176027273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.