Evidence map›Paper›PMID 34175978›Full record

ArticleEuropean journal of nutrition2022

Ketogenic diets consumed during radio-chemotherapy have beneficial effects on quality of life and metabolic health in patients with rectal cancer.

Rainer J Klement, Detlef Meyer, Stefan Kanzler, Reinhart A Sweeney

Registry-linked trialAbstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02516501 (Investigating the Impact of a Ketogenic Diet Intervention During Radiotherapy on Body Composition), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02516501 nacompletednot on this map

Investigating the Impact of a Ketogenic Diet Intervention During Radiotherapy on Body Composition: A Pilot Trial

TypeinterventionalSponsorMVZ Leopoldina GmbHRan2015 to 2021Enrolled156ConditionsNeoplasmsArmsMyAmino, betaquik, Radio(chemo)therapy
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  12. Nutrition, GH/IGF-1 signaling, and cancer.Endocrine-related cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rainer J KlementDepartment of Radiation Oncology, Leopoldina Hospital Schweinfurt, Robert-Koch-Straße 10, 97422, Schweinfurt, Germany. rainer_klement@gmx.de.ORCID http://orcid.org/0000-0003-1401-4270
Detlef MeyerDarmzentrum Leopoldina Hospital, Schweinfurt, Germany.
Stefan KanzlerDarmzentrum Leopoldina Hospital, Schweinfurt, Germany.
Reinhart A SweeneyDepartment of Radiation Oncology, Leopoldina Hospital Schweinfurt, Robert-Koch-Straße 10, 97422, Schweinfurt, Germany.
Leopoldina Krankenhaus Schweinfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInterest in ketogenic diets (KDs) as complementary nutritional treatments for cancer patients is rising, although some skepticism about their safety exists. We, therefore, studied the effects of KDs on quality of life and blood parameters in rectal cancer patients undergoing radio-chemotherapy.

methodsEORTC-QLQ30 questionnaire scores and different metabolic and hormonal blood parameters were obtained prior to, in the middle of and at the end of radiotherapy within the KETOCOMP study (ClinicalTrials.gov Identifier: NCT02516501). A total of 18 patients consuming a KD were compared to 23 patients consuming their standard diet (SD). Baseline-end differences were measured using Wilcoxon tests, and repeated measures analysis was performed using linear mixed effects models.

resultsEighty-nine percent of patients on the KD reported subjectively feeling good or very good, but roughly half of them rated the daily routine implementation as difficult. Only the SD group experienced significant declines in physical and role functioning, while the KD group improved in role (p = 0.045), emotional (p = 0.018) and social functioning (p = 0.009).Urinary frequency, buttock pain and fatigue significantly increased in the SD group, but to a much lesser extent in the KD group. Several biomarkers of metabolic health (gamma-glutamyl-transpeptidase, triglyceride-glucose index, HDL cholesterol/triglyceride ratio, and free T3) improved in the KD, but not the SD group.

conclusionsDespite being perceived as difficult to implement by ≈50% of patients, KDs are feasible as complementary therapies alongside radio-chemotherapy and associated with subjective well-being. The hypothesis that they exert beneficial effects on quality of life and metabolic health in rectal cancer patients is supported by our data.

trial registrationClinicalTrials.gov identifier NCT02516501, registered Aug 6th 2015.

Indexed as

Diet, KetogenicRectal NeoplasmsBody CompositionHumansQuality of LifeSurveys and QuestionnairesBlood parametersEORTC-QLQ30KETOCOMPKetone bodiesTyG index

Identifiers

PMID34175978
OpenAlexW3174242919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.