Evidence map›Paper›PMID 34175976›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2022

Malignant cerebral infarction associated with COVID-19 in a child.

Maria Rosaria Scala, Pietro Spennato, Domenico Cicala, Veronica Piccolo, Antonio Varone, Giuseppe Cinalli

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Advances in the Diagnosis and Treatment of Pediatric Arterial Ischemic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maria Rosaria ScalaDepartment of Neurosciences, Division of Neurosurgery, Santobono-Pausilipon Children's Hospital, Naples, Italy.
Pietro SpennatoDepartment of Neurosciences, Division of Neurosurgery, Santobono-Pausilipon Children's Hospital, Naples, Italy. pierospen@gmail.com.ORCID 0000-0001-7758-8605
Domenico CicalaDepartment of Neurosciences, Division of Neuroradiology, Santobono-Pausilipon Children's Hospital, Naples, Italy.
Veronica PiccoloDepartment of ICU, Santobono-Pausilipon Children's Hospital, Naples, Italy.
Antonio VaroneDepartment of Neurosciences, Division of Neurology, Santobono-Pausilipon Children's Hospital, Naples, Italy.
Giuseppe CinalliDepartment of Neurosciences, Division of Neurosurgery, Santobono-Pausilipon Children's Hospital, Naples, Italy.
Santobono Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurological manifestations, such as encephalitis, meningitis, ischemic, and hemorrhagic strokes, are reported with increasing frequency in patients affected by Coronavirus disease 2019 (COVID-19). In children, acute ischemic stroke is usually multifactorial: viral infection is an important precipitating factor for stroke. We present a case of a child with serological evidence of SARS-CoV-2 infection whose onset was a massive right cerebral artery ischemia that led to a malignant cerebral infarction. The patient underwent a life-saving decompressive hemicraniectomy, with good functional recovery, except for residual hemiplegia. During rehabilitation, the patient also developed a lower extremity peripheral nerve neuropathy, likely related to a long-Covid syndrome.

Indexed as

Brain IschemiaCOVID-19Decompressive CraniectomyStrokeCerebral InfarctionChildHumansInfarction, Middle Cerebral ArteryPost-Acute COVID-19 SyndromeSARS-CoV-2Treatment OutcomeAcute ischemic strokeDecompressive craniectomyLong-Covid syndromePeripheral nerve neuropathy

Identifiers

PMID34175976
PMCPMC8235910
OpenAlexW3174355061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.