Evidence map›Paper›PMID 34175956›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2022

Temporal changes and risk factors for death from early withdrawal within 12 months of dialysis initiation-a cohort study.

Jenny H C Chen, Mark A Brown, Matthew Jose, Frank Brennan, David W Johnson, Matthew A Roberts, Germaine Wong, Hicham Cheikh Hassan, Alice Kennard, Rachael Walker and 5 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Prognostication After Dialysis Withdrawal.Kidney international reports · 2024
    Article
  4. Review
  5. Article
  6. Using Relative Survival to Estimate the Burden of Kidney Failure.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 14 institutions in 2 countries.

Jenny H C ChenSchool of Medicine, University of Wollongong, Wollongong, Australia.
Mark A BrownDepartment of Nephrology, St George Hospital, Sydney, Australia.
Matthew JoseSchool of Medicine, The University of Tasmania, Hobart, Australia.
Frank BrennanDepartment of Nephrology, St George Hospital, Sydney, Australia.
David W JohnsonDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, Australia.
Matthew A RobertsSchool of Medicine, Monash University, Melbourne, Australia.
Germaine WongSydney School of Public Health, University of Sydney, Sydney, Australia.
Hicham Cheikh HassanSchool of Medicine, University of Wollongong, Wollongong, Australia.
Alice KennardSchool of Medicine, Australian National University, Canberra, Australia.
Rachael WalkerSydney School of Public Health, University of Sydney, Sydney, Australia.
Christopher E DaviesAustralia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, Adelaide, Australia.
Neil BoudvilleMedical School, University of Western Australia, Perth, Australia.
Monique BorlaceCentral Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia.
Carmel HawleyDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, Australia.
Wai H LimMedical School, University of Western Australia, Perth, Australia.
UNSW Sydney · AUAustralia and New Zealand Dialysis and Transplant Registry · AUCanberra Hospital · AUEastern Health · AUEastern Institute of Technology · NZKidney Health Australia · AUPrincess Alexandra Hospital · AURoyal Adelaide Hospital · AUSir Charles Gairdner Hospital · AUThe University of Sydney · AUThe University of Western Australia · AUUniversity of Tasmania · AUUniversity of Wollongong · AUWollongong Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMortality risk is high soon after dialysis initiation in patients with kidney failure, and dialysis withdrawal is a major cause of early mortality, attributed to psychosocial or medical reasons. The temporal trends and risk factors associated with cause-specific early dialysis withdrawal within 12 months of dialysis initiation remain uncertain.

methodsUsing data from the Australia and New Zealand Dialysis and Transplant Registry, we examined the temporal trends and risk factors associated with mortality attributed to early psychosocial and medical withdrawals in incident adult dialysis patients in Australia between 2005 and 2018 using adjusted competing risk analyses.

resultsOf 32 274 incident dialysis patients, 3390 (11%) experienced death within 12 months post-dialysis initiation. Of these, 1225 (36%) were attributed to dialysis withdrawal, with 484 (14%) psychosocial withdrawals and 741 (22%) medical withdrawals. These patterns remained unchanged over the past two decades. Factors associated with increased risk of death from early psychosocial and medical withdrawals were older age, dialysis via central venous catheter, late referral and the presence of cerebrovascular disease; obesity and Asian ethnicity were associated with decreased risk. Risk factors associated with early psychosocial withdrawals were underweight and higher socioeconomic status. Presence of peripheral vascular disease, chronic lung disease and cancers were associated with early medical withdrawals.

conclusionsDeath from dialysis withdrawal accounted for >30% of early deaths in kidney failure patients initiated on dialysis and remained unchanged over the past two decades. Several shared risk factors were observed between mortality attributed to early psychosocial and medical withdrawals.

Indexed as

Kidney Failure, ChronicRenal InsufficiencyAdultCohort StudiesFemaleHumansMaleRegistriesRenal DialysisRisk Factorsdialysisfrailtykidney supportive caremortalitytreatment withdrawal

Identifiers

PMID34175956
PMCPMC8951200
OpenAlexW3173347638

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.