Evidence map›Paper›PMID 34175929›Full record

ArticleAmerican journal of hypertension2021

Decision Tree-Based Classification for Maintaining Normal Blood Pressure Throughout Early Adulthood and Middle Age: Findings From the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Orna Reges, Amy E Krefman, Shakia T Hardy, Yuichiro Yano, Paul Muntner, Donald M Lloyd-Jones, Norrina B Allen

Open access · bronzeAbstract read
In one paragraph

Article in American journal of hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Tracking of blood pressure levels from childhood.Pediatric nephrology (Berlin, Germany) · 2025
    Review
  2. Article
  3. Article
  4. Factors influencing normal blood pressure maintenance in young adults.Journal of clinical hypertension (Greenwich, Conn.) · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Orna RegesDepartment of Preventive Medicine, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
Amy E KrefmanDepartment of Preventive Medicine, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
Shakia T HardyDepartment of Epidemiology, University of Alabama at Birmingham, School of Public Health, Birmingham, AL, USA.
Yuichiro YanoDepartment of Family Medicine and Community Health, Duke University School of Medicine, Durham, NC, USA.
Paul MuntnerDepartment of Epidemiology, University of Alabama at Birmingham, School of Public Health, Birmingham, AL, USA.
Donald M Lloyd-JonesDepartment of Preventive Medicine, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
Norrina B AllenDepartment of Preventive Medicine, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
Northwestern University · USUniversity of Alabama at Birmingham · USDuke University · US

Funding

Evaluating novel approaches for estimating awake and sleep blood pressureR01HL139716 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEVITAN, EMILY B, SHIMBO, DAICHI · 2018 to 2021
$3.4M
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS R01 HL139716
6 · The paper itself

Abstract

backgroundFor most individuals, blood pressure (BP) is related to multiple risk factors. By utilizing the decision tree analysis technique, this study aimed to identify the best discriminative risk factors and interactions that are associated with maintaining normal BP over 30 years and to reveal segments of a population with a high probability of maintaining normal BP.

methodsParticipants from the Coronary Artery Risk Development in Young Adults study aged 18-30 years with normal BP level at baseline visit (Y0, 1985-1986) were included in this study.

resultsOf 3,156 participants, 1,132 (35.9%) maintained normal BP during the follow-up period and 2,024 (64.1%) developed higher BP. Systolic BP (SBP) within the normal range, race, and body mass index (BMI) were the most discriminative factors between participants who maintained normal BP throughout midlife and those who developed higher BP. Participants with a baseline SBP level ≤92 mm Hg and White women with baseline BMI < 23 kg/m2 were the two segments of the population with the highest probability for maintaining normal BP throughout midlife (69.2% and 59.9%, respectively). Among Black participants aged >26.5 years with BMI > 27 kg/m2, only 5.4% of participants maintained normal BP throughout midlife.

conclusionsThis study emphasizes the importance of early life factors to later life SBP and support efforts to maintain ideal levels of risk factors for hypertension at young ages. Whether policies to maintain lower BMI and SBP well below the clinical thresholds throughout young adulthood and middle age can reduce later age hypertension should be examined in future studies.

Indexed as

Blood PressureHypertensionAdolescentAdultCoronary VesselsDecision TreesFemaleHumansMaleMiddle AgedRisk FactorsYoung Adultblood pressureCARDIA studydecision tree analysishypertension

Identifiers

PMID34175929
PMCPMC8557418
OpenAlexW3177207163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.