Evidence map›Paper›PMID 34175895›Full record

ArticleHeredity2021

Identification of the causative gene of a transparent phenotype of juvenile red sea bream Pagrus major.

Eitaro Sawayama, Yoshihiro Handa, Koichiro Nakano, Daiki Noguchi, Motohiro Takagi, Yosuke Akiba, Shuwa Sanada, Goro Yoshizaki, Hayato Usui, Kenta Kawamoto and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heredity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Eitaro SawayamaDepartment of Marine Science and Resources, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan. sawayama.eitaro@nihon-u.ac.jp.ORCID http://orcid.org/0000-0002-6831-6066
Yoshihiro HandaBioengineering Lab. Co., Ltd., Sagamihara, Kanagawa, Japan.
Koichiro NakanoBioengineering Lab. Co., Ltd., Sagamihara, Kanagawa, Japan.
Daiki NoguchiNippon Total Science, Inc., Fukuyama, Hiroshima, Japan.
Motohiro TakagiSouth Ehime Fisheries Research Center, Ehime University, Ehime, Japan.
Yosuke AkibaDepartment of Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo, Japan.
Shuwa SanadaDepartment of Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo, Japan.
Goro YoshizakiDepartment of Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo, Japan.
Hayato UsuiDepartment of Marine Science and Resources, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Kenta KawamotoDepartment of Marine Science and Resources, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Miwa SuzukiDepartment of Marine Science and Resources, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Kiyoshi AsahinaDepartment of Marine Science and Resources, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Nihon University · JPTokyo University of Marine Science and Technology · JPEhime University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deformities in cultured fish species may be genetic, and identifying causative genes is essential to expand production and maintain farmed animal welfare. We previously reported a genetic deformity in juvenile red sea bream, designated a transparent phenotype. To identify its causative gene, we conducted genome-wide linkage analysis and identified two single nucleotide polymorphisms (SNP) located on LG23 directly linked to the transparent phenotype. The scaffold on which the two SNPs were located contained two candidate genes, duox and duoxa, which are related to thyroid hormone synthesis. Four missense mutations were found in duox and one in duoxa, with that in duoxa showing perfect association with the transparent phenotype. The mutation of duoxa was suggested to affect the transmembrane structure and thyroid-related traits, including an enlarged thyroid gland and immature erythrocytes, and lower thyroxine (T

Indexed as

Sea BreamAnimalsGenetic LinkageHumansPhenotypeThyroid HormonesZebrafishThyroid Hormones

Identifiers

PMID34175895
PMCPMC8322342
OpenAlexW3176345862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.