Observational studyRespiratory medicine
Endothelial function provides early prognostic information in patients with COVID-19: A cohort study.
Observational study in Respiratory medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Persistent endothelial dysfunction is associated with exercise intolerance in adults despite preserved myocardial work 3 years after SARS-CoV-2 infection.Physiological reports · 2026Article
- A single bout of submaximal aerobic functional capacity test acutely promotes endothelial function in long COVID patients.Scientific reports · 2026Article
- Variability in Arterial Stiffness and Vascular Endothelial Function After COVID-19 During 1.5 Years of Follow-Up-Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- The impact of COVID-19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness?Physiological reports · 2025Article
- Non-Hospitalized Long COVID Patients Exhibit Reduced Retinal Capillary Perfusion: A Prospective Cohort Study.Journal of imaging · 2025Article
- Observational
- Cardiovascular damage and comorbidities related to long COVID: pathomechanisms, prevention, and therapy.Frontiers in cardiovascular medicine · 2025Review
- Inter- and intra-examiner reliability of short-term measurement of heart rate variability on rest in patients hospitalized with COVID-19.Scientific reports · 2024Article
- VEGF Polymorphisms (International journal of molecular sciences · 2024Article
- Clinical Implications of COVID-19-Related Endothelial Dysfunction.JACC. Advances · 2024Review
- Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies.Acta pharmacologica Sinica · 2023Review
- Endothelial dysfunction in acute and long standing COVID-19: A prospective cohort study.Vascular pharmacology · 2022Article
- Carotid intima-media thickness and flow-mediated dilation do not predict acute in-hospital outcomes in patients hospitalized with COVID-19.American journal of physiology. Heart and circulatory physiology · 2022Article
- Article
- ERS International Congress 2021: highlights from the Respiratory Clinical Care and Physiology Assembly.ERJ open research · 2022Review
- Hospital length of stay for COVID-19 patients: a systematic review and meta-analysis.Multidisciplinary respiratory medicine · 2022Article
- Persistent Endothelial Dysfunction in Coronavirus Disease-2019 Survivors Late After Recovery.Frontiers in medicine · 2022Article
- Effect of COVID-19 on endothelial function evaluated with flow-mediated dilation: another prognostic marker? A meta-analysis of observational studies.Archives of medical sciences. Atherosclerotic diseases · 2022Article
- Low Brachial Artery Flow-Mediated Dilation Predicts Worse Prognosis in Hospitalized Patients with COVID-19.Journal of clinical medicine · 2021Article
- Persistent Endothelial Dysfunction in Post-Acute COVID-19 Syndrome: A Case-Control Study.Biomedicines · 2021Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prothrombotic phenotype and diffuse intravascular coagulation observed in COVID-19 reflect endothelial dysfunction, which is linked to blood flow delivery deficiencies and cardiovascular risk. Assessments of detect vascular deficiencies among newly diagnosed and hospitalized patients due to COVID-19 have yet to be determined.
objectiveTo assess endothelial function characteristics in relation to length of hospitalization and mortality in patients diagnosed with COVID-19 and compare to patients without COVID-19.
methodsA prospective observational study involving 180 patients with confirmed COVID-19 (COVID-19 group) or suspected and ruled out COVID-19 (Non-COVID-19 group). Clinical evaluation and flow mediated vasodilation (FMD) were performed between the first 24-48 h of hospitalization. Patients were followed until death or discharge.
resultsWe evaluated 98 patients (COVID-19 group) and 82 (Non-COVID-19 group), COVID-19 group remained hospitalized longer and more deaths occurred compared to the Non-COVID-19 group (p = 0.01; and p < 0.01). Patients in COVID-19 group also had a significantly greater reduction in both FMDmm and FMD% (p < 0.01 in both). We found that absolute FMD≤0.26 mm and relative FMD≤3.43% were the ideal cutoff point to predict mortality and longer hospital stay. In Kaplan Meyer's analysis patients had a high probability of death within a period of up to 10 days of hospitalization.
conclusionPatients hospitalized for COVID-19 present endothelial vascular dysfunction early, remained hospitalized longer and had a higher number of deaths, when compared with patients without COVID-19.
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