ArticleLipids in health and disease2021
Associations between remnant lipoprotein cholesterol and central systolic blood pressure in a Chinese community-based population: a cross-sectional study.
Article in Lipids in health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 36 citations in OpenAlex.
- Cumulative exposure to remnant cholesterol and new-onset hypertension in middle-aged and older adults: a nationwide prospective cohort study with mediation analysis.Journal of human hypertension · 2026Article
- Exploring the relationship between residual cholesterol, body mass index, and hypertension risk: a national cohort study.Lipids in health and disease · 2025Observational
- Remnant cholesterol is associated with poor prognosis in patients with hepatitis B-related acute-on-chronic liver failure: a Chinese population-based study.Lipids in health and disease · 2025Article
- Combined and mediating effects of remnant cholesterol and renal function on hypertension risk in Chinese middle-aged and elderly people.Frontiers in endocrinology · 2025Article
- The association between residual cholesterol to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in elderly populations.Frontiers in endocrinology · 2025Article
- Remnant cholesterol, not LDL cholesterol, is associated with the risk of hypertension in the middle-aged and elderly population: Bushehr Elderly Health cohort.Frontiers in cardiovascular medicine · 2025Article
- Elevated remnant cholesterol was associated with the increased metabolically unhealthy obesity risk in Chinese youth.Asia Pacific journal of clinical nutrition · 2024Article
- Correlation between remnant cholesterol and hyperuricemia in patients with type 2 diabetes mellitus: a cross-sectional study.Lipids in health and disease · 2024Article
- Remnant cholesterol and risk of incident hypertension: a population-based prospective cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Association between remnant cholesterol and insulin resistance levels in patients with metabolic-associated fatty liver disease.Scientific reports · 2024Article
- Association of remnant cholesterol with hypertension, type 2 diabetes, and their coexistence: the mediating role of inflammation-related indicators.Lipids in health and disease · 2023Article
- The Association of Remnant Cholesterol with Endothelial Dysfunction and Subclinical Atherosclerosis in a Check-Up Population in China.Journal of atherosclerosis and thrombosis · 2023Article
- Remnant cholesterol can identify individuals at higher risk of metabolic syndrome in the general population.Scientific reports · 2023Article
- Association and mediating mechanism between remnant cholesterol and first-ever stroke among the Chinese general population.Frontiers in neuroscience · 2023Article
- Remnant cholesterol associates with hypertension beyond low-density lipoprotein cholesterol among the general US adult population.Frontiers in endocrinology · 2023Article
- Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver disease.BMC gastroenterology · 2022Article
- High Remnant Cholesterol Level Potentiates the Development of Hypertension.Frontiers in endocrinology · 2022Article
- Association of remnant cholesterol with nonalcoholic fatty liver disease: a general population-based study.Lipids in health and disease · 2021Article
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10 authors at 1 institution in 1 country.
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Abstract
backgroundThe lipid profile is reportedly related to peripheral blood pressure or pulse wave velocity. However, no studies have investigated the associations between lipid parameters, especially remnant lipoprotein cholesterol (RLP-C), and central systolic blood pressure (cSBP).
methodsThis study used baseline data of a community-based cohort in Beijing, China. Participants who had been treated with anti-hypertensive or lipid-lowering agents were excluded. RLP-C is equal to total cholesterol (TC) minus the sum of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). An Omron HEM-9000AI device was used to measure non-invasive cSBP. The associations between blood lipid profile and non-invasive cSBP were evaluated using multivariable regression models.
resultsThe 5173 included participants were 55.0 ± 8.5 years old; 35.7% (1845) of participants were men. Increased cSBP was significantly associated with increased TC, LDL-C, non-high-density lipoprotein cholesterol (non-HDL-C), triglyceride (TG), and RLP-C but with decreased HDL-C, even after adjusting for possible covariates. When simultaneously entering individual pairs of RLP-C and other blood lipid parameters into the multivariable regression model, RLP-C remained significantly associated with cSBP, even after adjusting for other lipids. Compared with participants who had RLP-C levels in the first quartile (Q1), cSBP for those with RLP-C in Q4 was increased to 4.57 (95% confidence interval [CI]: 3.08-6.06) mmHg after adjusting for LDL-C, 4.50 (95%CI: 2.98-6.02) mmHg after adjusting for TC, 3.91 (95%CI: 1.92-5.89) mmHg after adjusting for TG, 5.15 (95%CI: 3.67-6.63) mmHg after adjusting for HDL-C, and 4.10 (95%CI: 2.36-5.84) mmHg after adjusting for non-HDL-C.
conclusionsIncreased blood RLP-C level was significantly associated with higher cSBP in a Chinese population, independently of other lipids, which indicates its importance in individual cardiovascular risk assessment.
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