Evidence map›Paper›PMID 34174748›Full record

ArticleMedical image analysis2021

A deep joint sparse non-negative matrix factorization framework for identifying the common and subject-specific functional units of tongue motion during speech.

Jonghye Woo, Fangxu Xing, Jerry L Prince, Maureen Stone, Arnold D Gomez, Timothy G Reese, Van J Wedeen, Georges El Fakhri

Open access · greenAbstract read
In one paragraph

Article in Medical image analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Speech Motion Anomaly Detection via Cross-Modal Translation of 4D Motion Fields from Tagged MRI.Proceedings of SPIE--the International Society for Optical Engineering · 2024
    Article
  3. Review
  4. Speech Audio Synthesis from Tagged MRI and Non-Negative Matrix Factorization via Plastic Transformer.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
    Article
  5. Synthesizing Audio from Tongue Motion During Speech Using Tagged MRI Via Transformer.Proceedings of SPIE--the International Society for Optical Engineering · 2023
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jonghye WooGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: jwoo@mgh.harvard.edu.
Fangxu XingGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Jerry L PrinceDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Maureen StoneDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
Arnold D GomezDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA.
Timothy G ReeseAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Van J WedeenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Georges El FakhriGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Harvard University · USJohns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Kira Grogg · 2017 to 2026
$14.8M
A holistic approach to identifying functional units of tongue motion during speechR01DC018511 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI WOO, JONGHYE · 2020 to 2024
$2.6M
Predictors of Speech Quality after Tongue Cancer SurgeryR01CA133015 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI STONE, MAUREEN · 2009 to 2013
$2.5M
Tongue muscle function after cancer surgery using 4D MRI, DTI, and MR taggingR01DC014717 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2015 to 2019
$1.7M
4D Statistical Atlas from Multimodal Tongue MR ImagesR00DC012575 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI WOO, JONGHYE · 2015 to 2017
$746k
In Vivo Mapping of Uncharted Functional Units of Tongue Motion During SpeechR21DC016047 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI WOO, JONGHYE · 2018 to 2019
$460k
NCI NIH HHS R01 CA133015NIBIB NIH HHS P41 EB022544NIDCD NIH HHS R00 DC012575NIDCD NIH HHS R01 DC014717NIDCD NIH HHS R01 DC018511NIDCD NIH HHS R21 DC016047
6 · The paper itself

Abstract

Intelligible speech is produced by creating varying internal local muscle groupings-i.e., functional units-that are generated in a systematic and coordinated manner. There are two major challenges in characterizing and analyzing functional units. First, due to the complex and convoluted nature of tongue structure and function, it is of great importance to develop a method that can accurately decode complex muscle coordination patterns during speech. Second, it is challenging to keep identified functional units across subjects comparable due to their substantial variability. In this work, to address these challenges, we develop a new deep learning framework to identify common and subject-specific functional units of tongue motion during speech. Our framework hinges on joint deep graph-regularized sparse non-negative matrix factorization (NMF) using motion quantities derived from displacements by tagged Magnetic Resonance Imaging. More specifically, we transform NMF with sparse and graph regularizations into modular architectures akin to deep neural networks by means of unfolding the Iterative Shrinkage-Thresholding Algorithm to learn interpretable building blocks and associated weighting map. We then apply spectral clustering to common and subject-specific weighting maps from which we jointly determine the common and subject-specific functional units. Experiments carried out with simulated datasets show that the proposed method achieved on par or better clustering performance over the comparison methods.Experiments carried out with in vivo tongue motion data show that the proposed method can determine the common and subject-specific functional units with increased interpretability and decreased size variability.

Indexed as

AlgorithmsSpeechHumansMagnetic Resonance ImagingNeural Networks, ComputerTongueDeep non-negative matrix factorizationFunctional unitsTagged-MRITongue motion

Identifiers

PMID34174748
PMCPMC8316408
OpenAlexW3041303780

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.