Evidence map›Paper›PMID 34174676›Full record

ArticleClinical biomechanics (Bristol, Avon)2021

A biomechanically-guided planning and execution paradigm for osteoporotic hip augmentation: Experimental evaluation of the biomechanics and temperature-rise.

Amirhossein Farvardin, Mahsan Bakhtiarinejad, Ryan J Murphy, Ehsan Basafa, Harpal Khanuja, Juluis K Oni, Mehran Armand

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Amirhossein FarvardinDepartment of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA; Laboratory for Computational Sensing and Robotics, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA. Electronic address: afarvar1@jhu.edu.
Mahsan BakhtiarinejadDepartment of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA; Laboratory for Computational Sensing and Robotics, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
Ryan J MurphyAuris Health, Inc., 150 Shoreline Dr, Redwood City, CA 94065, USA.
Ehsan BasafaAuris Health, Inc., 150 Shoreline Dr, Redwood City, CA 94065, USA.
Harpal KhanujaDepartment of Orthopaedic Surgery, Johns Hopkins University, 601 N. Caroline Street, Baltimore, MD 21287, USA.
Juluis K OniDepartment of Orthopaedic Surgery, Johns Hopkins University, 601 N. Caroline Street, Baltimore, MD 21287, USA.
Mehran ArmandDepartment of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA; Laboratory for Computational Sensing and Robotics, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA; Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Rd, Laurel, MD 20723, USA; Department of Orthopaedic Surgery, Johns Hopkins University, 601 N. Caroline Street, Baltimore, MD 21287, USA.
Johns Hopkins University · USAuris Health (United States) · USJohns Hopkins University Applied Physics Laboratory · US

Funding

Robot-Assisted Femoroplasty with Intraoperative Biomechanical FeedbackR01EB023939 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ARMAND, MEHRAN · 2017 to 2020
$1.6M
Preoperative Planning of FemoroplastyR21AR063815 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARMAND, MEHRAN · 2013 to 2014
$346k
NIAMS NIH HHS R21 AR063815NIBIB NIH HHS R01 EB023939
6 · The paper itself

Abstract

backgroundAugmentation of the proximal femur with bone cement (femoroplasty) has been identified as a potential preventive approach to reduce the risk of fracture. Femoroplasty, however, is associated with a risk of thermal damage as well as the leakage of bone cement or blockage of blood supply when large volumes of cement are introduced inside the bone.

methodsSix pairs of cadaveric femora were augmented using a newly proposed planning paradigm and an in-house navigation system to control the location and volume of the injected cement. To evaluate the risk of thermal damage, we recorded the peak temperature of bone at three regions of interest as well as the exposure time for temperature rise of 8 °C, 10 °C, and 12 °C in these regions. Augmentation was followed by mechanical testing to failure resembling a sideway fall on the greater trochanter.

findingsResults of the fracture tests correlated with those of simulations for the yield load (R

interpretationThe new planning paradigm offers a more efficient injection strategy with injection volume of 9.1 ml on average. Meanwhile, temperature recordings of bone surfaces suggest that risk of thermal necrosis remains as a concern with femoroplasty using Polymethylmethacrylate.

Indexed as

Bone CementsPolymethyl MethacrylateBiomechanical PhenomenaFemur NeckHumansTemperatureBone CementsPolymethyl MethacrylateFinite element analysisOsteoporotic hip augmentationPMMA cementSurgical planning

Identifiers

PMID34174676
PMCPMC8550980
OpenAlexW3167268181

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.