Evidence map›Paper›PMID 34174434›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

Contact tracing is associated with treatment success of index tuberculosis cases in Uganda.

Joseph Baruch Baluku, Rachael Alele Kabamooli, Norah Kajumba, Martin Nabwana, David Kateete, Sarah Kiguli, Irene Andia-Biraro

Abstract read
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph Baruch BalukuKiruddu National Referral Hospital, Kampala, Uganda; Makerere University Lung Institute, Kampala, Uganda. Electronic address: bbjoe18@gmail.com.
Rachael Alele KabamooliKitebi Health Center, Kampala, Uganda.
Norah KajumbaKitebi Health Center, Kampala, Uganda.
Martin NabwanaMakerere University - Johns Hopkins University Research Collaboration, Kampala, Uganda.
David KateeteDepartment of Microbiology and Immunology, Makerere University College of Health Sciences.
Sarah KiguliDepartment of Paediatrics and Child Health, Makerere University College of Health Sciences.
Irene Andia-BiraroDepartment of Internal Medicine, Makerere University College of Health Sciences.

Funding

Health Professions Education and training for strengthening the health system and services in UgandaR25TW011213 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI KIGULI, SARAH · 2018 to 2022
$3.4M
FIC NIH HHS R25 TW011213Medical Research Council MR/P028071/1
6 · The paper itself

Abstract

objectiveTo determine the effect of contact tracing on the treatment outcomes of index tuberculosis (TB) cases in Uganda.

methodsWe evaluated TB cases registered at an urban public health facility in Uganda in 2015-2020. We extracted data from the unit's TB and contact tracing registers. Treatment outcomes were classified as cure, loss to follow-up, death and treatment failure. Treatment success was the sum of cure and treatment completion.

resultsAmong 778 TB cases, contact tracing was conducted for 455 (58.5%). Compared with cases without contract tracing (n=323), cases with contract tracing (n=455) had higher treatment success (92.5% vs 79.3%) and cure rates (57.1% vs 39.9%) and lower loss to follow-up (3.5% vs 9.3%), treatment failure (0.4% vs 1.6%) and death (3.5% vs 9.9%) (P<0.001). Contact tracing was associated with higher odds of treatment success (adjusted odds ratio (aOR) 3.00, 95% CI 1.92-4.70, P<0.001) and cure (aOR 3.11, 95% CI 1.97-4.90, P<0.001), and lower odds of loss to follow-up (aOR 0.33, (0.13-0.83), P=0.018) and death (aOR 0.38, (0.20-0.72), P=0.003).

conclusionTB contact tracing should be conducted consistently not only for the benefit of identifying new TB cases but also to promote treatment success of index cases.

Indexed as

Contact TracingTuberculosisHumansTreatment FailureTreatment OutcomeUgandacontact tracinginvestigationoutcomessuccesstuberculosisUganda

Identifiers

PMID34174434
PMCPMC9395259

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.