Evidence map›Paper›PMID 34174431›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

The Molecular Epidemiology and Clinical Phylogenetics of Rhinoviruses Among Paediatric Cases in Sydney, Australia.

Dillon Charles Adam, Xin Chen, Matthew Scotch, Chandini Raina MacIntyre, Dominic Dwyer, Jen Kok

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Genotypic Diversity of Childhood Rhinovirus Infections.Journal of the Pediatric Infectious Diseases Society · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Dillon Charles AdamBiosecurity Program, The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Xin ChenBiosecurity Program, The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia. Electronic address: xinjessiechen@protonmail.com.
Matthew ScotchBiosecurity Program, The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia; Biodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, Tempe, AZ, USA; College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Chandini Raina MacIntyreBiosecurity Program, The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia; College of Public Service & Community Solutions, Arizona State University, Tempe, AZ, USA.
Dominic DwyerInstitute for Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital and University of Sydney, Sydney, Australia.
Jen KokInstitute for Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital and University of Sydney, Sydney, Australia.
UNSW Sydney · AUThe University of Sydney · AU

Funding

Merging Viral Genetics with Climate and Population Data for Zoonotic SurveillanceR01LM012080 · NLM · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI SCOTCH, MATTHEW · 2015 to 2017
$1.1M
NLM NIH HHS R01 LM012080
6 · The paper itself

Abstract

objectivesRhinoviruses (RV) represent the most common aetiological agent of all acute respiratory tract infections across all age groups and a significant burden of disease among children. Recent studies have shown that RV-A and RV-C species are associated with increased disease severity. In order to better understand the potential associations between RV species and clinical features among paediatric cases, this study aimed to integrate genetic and epidemiological data using Bayesian phylogenetic methods.

methodsPotential associations between RV species and subtypes, and clinical disease severity using a matched dataset of 52 RV isolates sampled from children (< 18 years) in Sydney, Australia, between 2006 and 2009 were uncovered using epidemiological and phylogenetic methods.

resultsIt was found that RV-C was significantly more likely to be isolated from paediatric cases aged < 2 years compared with RV-A, although no significant differences in recorded symptoms were observed. Significant phylogenetic-trait associations between age and the VP4/VP2 capsid protein phylogeny suggest that age-specific variations in infectivity among subtypes may may be possible.

conclusionThis study adds to the growing body of epidemiological evidence concerning RV. Improving surveillance and testing for RV, including routine whole genome sequencing, may improve understanding of the varied disease outcomes of RV species and subtypes. Future studies could aim to identify specific genetic markers associated with age-specific infectivity of RV, which could inform treatment practices and public health surveillance of RV.

Indexed as

Picornaviridae InfectionsRespiratory Tract InfectionsBayes TheoremChildHumansMolecular EpidemiologyPhylogenyRhinovirusEpidemiologyPaediatric infectionsPhylogeneticsRhinoviruses

Identifiers

PMID34174431
PMCPMC10161873
OpenAlexW3174376681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.