Evidence map›Paper›PMID 34174086›Full record

ArticleThe Journal of physiology2021

COVID-19 is getting on our nerves: sympathetic neural activity and haemodynamics in young adults recovering from SARS-CoV-2.

Nina L Stute, Jonathon L Stickford, Valesha M Province, Marc A Augenreich, Stephen M Ratchford, Abigail S L Stickford

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 90 citations in OpenAlex.

  1. Article
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  5. Cardiac Baroreflex Is Preserved After the Recovery From COVID-19 Men and Women.Journal of clinical hypertension (Greenwich, Conn.) · 2025
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  6. Review
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  10. Cognitive disengagement syndrome in pediatric patients with long COVID: associations with mood, anxiety, and functional impairment.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Neurovascular and hemodynamic responses to mental stress and exercise in severe COVID-19 survivors.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nina L StuteDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.ORCID 0000-0001-8213-638X
Jonathon L StickfordDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.
Valesha M ProvinceDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.ORCID 0000-0002-8259-7693
Marc A AugenreichDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.
Stephen M RatchfordDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.ORCID 0000-0002-6300-7600
Abigail S L StickfordDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.ORCID 0000-0002-1856-1274
Appalachian State University · US

Funding

Internal COVID-19 Research Cluster Award at Appalachian State University
6 · The paper itself

Abstract

key pointsThe impact of SARS-CoV-2 infection on autonomic and cardiovascular function in otherwise healthy individuals is unknown. For the first time it is shown that young adults recovering from SARS-CoV-2 have elevated resting sympathetic activity, but similar heart rate and blood pressure, compared with control subjects. Survivors of SARS-CoV-2 also exhibit similar sympathetic nerve activity and haemodynamics, but decreased pain perception, during a cold pressor test compared with healthy controls. Further, these individuals display higher sympathetic nerve activity throughout an orthostatic challenge, as well as an exaggerated heart rate response to orthostasis. If similar autonomic dysregulation, like that found here in young individuals, is present in older adults following SARS-CoV-2 infection, there may be substantial adverse implications for cardiovascular health. ABSTRACT: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can elicit systemic adverse physiological effects. However, the impact of SARS-CoV-2 on autonomic and cardiovascular function in otherwise healthy individuals remains unclear. Young adults who tested positive for SARS-CoV-2 (COV+; n = 16, 8 F) visited the laboratory 35 ± 16 days following diagnosis. Muscle sympathetic nerve activity (MSNA), systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) were measured in participants at rest and during a 2 min cold pressor test (CPT) and 5 min each at 30° and 60° head-up tilt (HUT). Data were compared with age-matched healthy controls (CON; n = 14, 9 F). COV+ participants (18.2 ± 6.6 bursts min

Indexed as

COVID-19SARS-CoV-2AgedBlood PressureHeart RateHemodynamicsHumansMuscle, SkeletalSympathetic Nervous SystemYoung Adultautonomic functioncold pressor testCOVID-19heart rate variabilityMSNAorthostatic

Identifiers

PMID34174086
PMCPMC8447023
OpenAlexW3174150076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.