ArticleJournal of cancer survivorship : research and practice2022
Association of cognitive impairment and breast cancer survivorship on quality of life in younger breast cancer survivors.
Article in Journal of cancer survivorship : research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE): A randomized controlled trial.Cancer · 2025Trial
- Trial
- Accounting for unmet needs resulting from cancer-related cognitive impairment.Journal of cancer survivorship : research and practice · 2026Article
- Symptom burden in cancer survivorship: insights from a survivorship program's patient-reported outcomes database.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- "I had to work it out for myself": opportunities for primary care to fill a void for early-onset breast cancer survivors.Journal of cancer survivorship : research and practice · 2026Article
- Self-efficacy in the managing late sequelae in long-term breast cancer survivors in Spain.Scientific reports · 2026Article
- Article
- The relationship between alexithymia, meaning in life, and quality of life in older breast cancer patients: a cross-sectional study based on variable-centered and person-centered perspectives.Frontiers in medicine · 2026Article
- Limitations of standard memory assessments in breast cancer survivors.Translational neuroscience · 2026Article
- The potential of microbiome modulators to improve quality of life in cancer survivors through gut microbiome-immune interactions.Frontiers in molecular neuroscience · 2026Review
- Establishing the Ecological Validity of Cognitive Patient Reported Outcome Measures in Breast Cancer Survivors: A Prospective Cohort Study.Psycho-oncology · 2025Article
- The association of the MIND diet and its components with cognitive function in postmenopausal breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Quality of life in long-term cancer-free breast cancer survivors in spain: A descriptive study.Scientific reports · 2025Article
- Incidence and predictors of immune checkpoint inhibitor treatment-related cognitive impairment in a racial and ethnic diverse population.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Article
- Changes of perioperative cognitive function and its effect on quality of life in laryngeal cancer.Perioperative medicine (London, England) · 2025Article
- Virtual Reality to Improve the Psychological and Physical Well-Being in Cancer Patients: An Umbrella Review.Cancers · 2024Review
- Association between Cognitive Function and Physical Function, Frailty, and Quality of Life in Older Breast Cancer Survivors.Cancers · 2024Article
- Qigong in the care of breast cancer survivors with diabetes.Asia-Pacific journal of oncology nursing · 2024Article
- The Association between Relationship Satisfaction Concordance and Breast Cancer Survivors' Physical and Psychosocial Well-Being.Healthcare (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
purposeYounger breast cancer survivors (BCS) often report cognitive impairment and poor quality of life (QoL), which could be interrelated. The purpose of this study was to examine the association of cognitive impairment and breast cancer status (BCS versus healthy control (HC)), with QoL, which included psychological (depressive symptoms, well-being, perceived stress, and personal growth) and physical well-being (physical functioning and fatigue).
methodsFour hundred ninety-eight BCS (≤45 years at diagnosis) who were 3 to 8 years post-chemotherapy treatment and 394 HC completed subjective questionnaires and a one-time neuropsychological assessment, including tests of attention, memory, processing speed, and verbal fluency. For each test, cognitive impairment was defined as scoring 1.5 and 2.0 standard deviations below the mean of the HC group. Separate linear regression models for each outcome were ran controlling for known covariates.
resultsBCS reported significantly more memory problems than HC (p < 0.0001), with up to 23% having significant impairment. Cognitive performance did not differ significantly between BCS and HCs. BCS vs. HCs had greater depression and fatigue, yet more personal growth. Objective and subjective cognitive impairment were significantly related to greater depressive symptoms and perceived stress and lower well-being and physical functioning; whereas, objective impairment was related to less personal growth and subjective impairment was related to greater fatigue.
conclusionsYounger BCS report significant cognitive impairment years after treatment which may relate to greater decrements in QoL. IMPLICATIONS TO CANCER SURVIVORS: Assessment and interventions to address cognitive concerns may also influence QoL outcomes in younger BCS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.