Evidence map›Paper›PMID 34173922›Full record

ReviewMetabolic brain disease2021

How cytosolic compartments play safeguard functions against neuroinflammation and cell death in cerebral ischemia.

Fari Ryan, Seyed Esmaeil Khoshnam, Fariba Khodagholi, Ghorbangol Ashabi, Abolhassan Ahmadiani

Abstract readReview
PubMed Publisher
In one paragraph

Review in Metabolic brain disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Fari RyanCentre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Seyed Esmaeil KhoshnamPersian Gulf Physiology Research Centre, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Fariba KhodagholiNeuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ghorbangol AshabiDepartment of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, PO Box: 1417613151, Tehran, Iran. gh-ashabi@tums.ac.ir.
Abolhassan AhmadianiNeuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. aahmadiani@yahoo.com.
Shahid Beheshti University of Medical Sciences · IRAhvaz Jundishapur University of Medical Sciences · IRMcGill University Health Centre · CATehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is the second leading cause of mortality and disability globally. Neuronal damage following ischemic stroke is rapid and irreversible, and eventually results in neuronal death. In addition to activation of cell death signaling, neuroinflammation is also considered as another pathogenesis that can occur within hours after cerebral ischemia. Under physiological conditions, subcellular organelles play a substantial role in neuronal functionality and viability. However, their functions can be remarkably perturbed under neurological disorders, particularly cerebral ischemia. Therefore, their biochemical and structural response has a determining role in the sequel of neuronal cells and the progression of disease. However, their effects on cell death and neuroinflammation, as major underlying mechanisms of ischemic stroke, are still not understood. This review aims to provide a comprehensive overview of the contribution of each organelle on these pathological processes after ischemic stroke.

Indexed as

AnimalsCell DeathCytosolEndoplasmic ReticulumGolgi ApparatusHumansIschemic StrokeNeuroinflammatory DiseasesNeuronsNLR Family, Pyrin Domain-Containing 3 ProteinOrganellesPeroxisomesRibosomesNLR Family, Pyrin Domain-Containing 3 ProteinCell deathCellular organellesCerebral ischemiaNeuroinflammationStroke

Identifiers

PMID34173922
OpenAlexW3176846329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.