Evidence map›Paper›PMID 34173895›Full record

Trial reportAIDS and behavior2022

Act Healthy: A Randomized Clinical Trial Evaluating a Behavioral Activation Intervention to Address Substance Use and Medication Adherence Among Low-Income, Black/African American Individuals Living with HIV/AIDS.

Jessica F Magidson, Jennifer M Belus, C J Seitz-Brown, Hannah Tralka, Steven A Safren, Stacey B Daughters

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01351454 (Behavioral Depression Treatment for African American HIV-infected Substance Users), which is not on this map. Cited by 12 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 5 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01351454 nacompletednot on this map

Behavioral Depression Treatment for African American HIV-infected Substance Users

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2008 to 2013Enrolled61ConditionsDepression, Substance UseArmsACT HEALTHY, Nondirective Therapy (NDT)
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 5 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  6. Trial
  7. Leveraging virtual reality to improve medication adherence among marginalized populations with high-risk chronic health conditions: Proof-of-concept protocol, considerations, and next steps.Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jessica F MagidsonDepartment of Psychology, University of Maryland, 4094 Campus Drive, College Park, Maryland, USA. jmagidso@umd.edu.ORCID http://orcid.org/0000-0002-3513-3255
Jennifer M BelusDepartment of Psychology, University of Maryland, 4094 Campus Drive, College Park, Maryland, USA.
C J Seitz-BrownDepartment of Psychology, University of Maryland, 4094 Campus Drive, College Park, Maryland, USA.
Hannah TralkaDepartment of Psychology, University of Maryland, 4094 Campus Drive, College Park, Maryland, USA.
Steven A SafrenDepartment of Psychology, University of Miami, Miami, FL, USA.
Stacey B DaughtersDepartment of Psychology and Neuroscience, UNC Chapel-Hill, Chapel Hill, NC, USA.
University of Maryland, College Park · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · US

Funding

University of Miami Developmental HIV/AIDS Mental Health Research Center (D-ARC)P30MH116867 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2019 to 2023
$6.5M
Behavioral Depression Treatment for African American HIV-infected Substance UsersR01DA022974 · NIDA · UNIV OF MARYLAND, COLLEGE PARK · PI LEJUEZ, CARL W · 2008 to 2011
$1.4M
NIDA NIH HHS R01 DA022974NIDA NIH HHS R01DA022974NIMH NIH HHS P30 MH116867
6 · The paper itself

Abstract

There is a need for parsimonious behavioral interventions to support HIV and substance use treatment outcomes for low-income, Black/African American individuals living with HIV. This randomized clinical trial (N = 61) evaluated Act Healthy (AH), an integrated behavioral intervention to reduce substance use and improve medication adherence, compared to supportive counseling (SC) plus Life-Steps medication adherence counseling on substance use, craving, adherence-related outcomes, and depression over one year. Participants in AH had significantly steeper decreases in cravings compared to SC, but no significant differences in substance use. Across both groups, there was a significant increase in probability of being on antiretroviral therapy (ART) (86% on ART at 12 months vs. 56% at baseline), and a significant decrease in medication nonadherence. Findings provide preliminary support for an intervention to reduce cravings and strategies to improve ART use in a hard-to-reach, vulnerable population at high risk for poor treatment outcomes and ongoing HIV transmission.

trial registrationClinicalTrials.gov trial registration number: identifier: NCT01351454. Retrospectively registered on May 10, 2011.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsSubstance-Related DisordersBlack or African AmericanHumansMedication AdherenceBehavioral interventionHealth disparitiesHIV/AIDSMinority healthSubstance use disorder

Identifiers

PMID34173895
PMCPMC8808422
OpenAlexW3174621492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.