Evidence map›Paper›PMID 34173882›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2021

Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes.

Mickaël Marloye, Haider Inam, Connor J Moore, Vinciane Debaille, Justin R Pritchard, Michel Gelbcke, Franck Meyer, François Dufrasne, Gilles Berger

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Synthesis, characterization, and biological activity of cationic ruthenium-arene complexes with sulfur ligands.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mickaël MarloyeMicrobiology, Bioorganic and Macromolecular Chemistry, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), 1050, Brussels, Belgium.
Haider InamDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA.
Connor J MooreDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA.
Vinciane DebailleLaboratoire G-Time, Université Libre de Bruxelles, 1050, Brussels, Belgium.
Justin R PritchardDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA.
Michel GelbckeMicrobiology, Bioorganic and Macromolecular Chemistry, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), 1050, Brussels, Belgium.
Franck MeyerMicrobiology, Bioorganic and Macromolecular Chemistry, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), 1050, Brussels, Belgium.
François DufrasneMicrobiology, Bioorganic and Macromolecular Chemistry, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), 1050, Brussels, Belgium.
Gilles BergerMicrobiology, Bioorganic and Macromolecular Chemistry, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), 1050, Brussels, Belgium. gilles.berger@ulb.be.
Université Libre de Bruxelles · BEPennsylvania State University · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ruthenium (Ru) and osmium (Os) complexes are of sustained interest in cancer research and may be alternative to platinum-based therapy. We detail here three new series of ruthenium and osmium complexes, supported by physico-chemical characterizations, including time-dependent density functional theory, a combined experimental and computational study on the aquation reactions and the nature of the metal-arene bond. Cytotoxic profiles were then evaluated on several cancer cell lines although with limited success. Further investigations were, however, performed on the most active series using a genetic approach based on RNA interference and highlighted a potential multi-target mechanism of action through topoisomerase II, mitotic spindle, HDAC and DNMT inhibition.

Indexed as

AnimalsAntineoplastic AgentsBiotinCell Line, TumorCell ProliferationCell SurvivalCoordination ComplexesCrystallography, X-RayDensity Functional TheoryDrug Screening Assays, AntitumorHumansMiceModels, MolecularMolecular StructureMorpholinesOsmiumAntineoplastic AgentsBiotinCoordination ComplexesmorpholineMorpholinesOsmiumRutheniumAnticancer complexCell targetingMetal–areneMetallodrugshRNA profiling

Identifiers

PMID34173882
OpenAlexW3173678421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.