Evidence map›Paper›PMID 34173845›Full record

ArticleWorld journal of urology2021

Development of a nomogram predicting the probability of stone free rate in patients with ureteral stones eligible for semi-rigid primary laser uretero-litothripsy.

Cosimo De Nunzio, Jamil Ghahhari, Riccardo Lombardo, Giorgio Ivan Russo, Ana Albano, Antonio Franco, Valeria Baldassarri, Antonio Nacchia, Juan Lopez, Pilar Luque and 3 more

Abstract read
In one paragraph

Article in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cosimo De NunzioDepartment of Urology, "Sant'Andrea" Hospital, "La Sapienza" University, Rome, Italy. cosimodenunzio@virgilio.it.ORCID http://orcid.org/0000-0002-2190-512X
Jamil GhahhariDepartment of Urology, "Sant'Andrea" Hospital, "La Sapienza" University, Rome, Italy.
Riccardo LombardoDepartment of Urology, "Sant'Andrea" Hospital, "La Sapienza" University, Rome, Italy.
Giorgio Ivan RussoDepartment of Urology, "Sant'Andrea" Hospital, "La Sapienza" University, Rome, Italy.
Ana AlbanoHospital Clinic Barcelona, Barcelona, Spain.
Antonio FrancoDepartment of Urology, "Sant'Andrea" Hospital, "La Sapienza" University, Rome, Italy.
Valeria BaldassarriDepartment of Urology, "Sant'Andrea" Hospital, "La Sapienza" University, Rome, Italy.
Antonio NacchiaDepartment of Urology, "Sant'Andrea" Hospital, "La Sapienza" University, Rome, Italy.
Juan LopezHospital Clinic Barcelona, Barcelona, Spain.
Pilar LuqueHospital Clinic Barcelona, Barcelona, Spain.
Maria Jose RibalHospital Clinic Barcelona, Barcelona, Spain.
Antonio AlcarazHospital Clinic Barcelona, Barcelona, Spain.
Andrea TubaroDepartment of Urology, "Sant'Andrea" Hospital, "La Sapienza" University, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFew tools are available to predict uretero-lithotripsy outcomes in patients with ureteral stones. Aim of our study was to develop a nomogram predicting the probability of stone free rate in patients undergoing semi-rigid uretero-lithotripsy (ULT) for ureteral stones.

methodsFrom January 2014 onwards, patients undergoing semi-rigid Ho: YAG laser uretero-lithotripsy for ureteral stones were prospectively enrolled in two centers. Patients were preoperatively evaluated with accurate clinical history, urinalysis and renal function. Non-contrast CT was used to define number, location and length of the stones and eventually the presence of hydronephrosis. A nomogram was generated based on the logistic regression model used to predict ULT success.

resultsOverall, 356 patients with mean age of 54 years (IQR 44/65) were enrolled. 285/356 (80%) patients were stone free at 1 month. On multivariate analysis single stone (OR 1.93, 95% CI 1.05-3.53, p = 0.034), stone size (OR 0.92, 95% CI 0.87-0.97, p = 0.005), distal position (OR 2.12, 95% CI 1.29-3.48, p = 0.003) and the absence of hydronephrosis (OR 2.02, 95% CI 1.08-3.78, p = 0.029) were predictors of success and these were used to develop a nomogram. The nomogram based on the model presented good discrimination (area under the curve [AUC]: 0.75), good calibration (Hosmer-Lemeshow test, p > 0.5) and a net benefit in the range of probabilities between 15 and 65%. Internal validation resulted in an AUC of 0.74.

conclusionsThe implementation of our nomogram could better council patients before treatment and could be used to identify patients at risk of failure. External validation is warranted before its clinical implementation.

Indexed as

NomogramsAdultAgedFemaleHumansLithotripsy, LaserMaleMiddle AgedTreatment OutcomeUreteral CalculiStone freeTreatmentUreteral stonesUreterolitothripsy

Identifiers

PMID34173845
PMCPMC8571227

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.