Evidence map›Paper›PMID 34173268›Full record

ArticleMagnetic resonance in medicine2021

Denoising of hyperpolarized

Yaewon Kim, Hsin-Yu Chen, Adam W Autry, Javier Villanueva-Meyer, Susan M Chang, Yan Li, Peder E Z Larson, Jeffrey R Brender, Murali C Krishna, Duan Xu and 2 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. A Static Phantom for Harmonization of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  5. Biocompatible SABRE Hyperpolarization of [1-Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Clinical Translation of HyperpolarizedAJNR. American journal of neuroradiology · 2025
    Review
  12. Article
  13. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  14. Article
  15. Assessment of the Feasibility of Hyperpolarized [1-Journal of magnetic resonance imaging : JMRI · 2024
    Article
  16. Article
  17. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  18. HyperpolarizedMagnetic resonance in medicine · 2024
    Article
  19. Article
  20. Tensor Methods in Biomedical Image Analysis.Journal of medical signals and sensors · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yaewon KimDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID 0000-0003-1016-1572
Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID 0000-0002-2765-1685
Adam W AutryDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Javier Villanueva-MeyerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Susan M ChangDepartment of Neurological Surgery, University of California, San Francisco, California, USA.
Yan LiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID 0000-0003-4183-3634
Jeffrey R BrenderCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Murali C KrishnaCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Duan XuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID 0000-0003-2760-4886

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4M
Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang, Janine Marie Lupo · 2007 to 2026
$44.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
NCI NIH HHS P01 CA118816NCI NIH HHS P50 CA097257NCI NIH HHS T32 CA151022NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

purposeTo improve hyperpolarized

methodsThe benefit of using a patch-based HOSVD method to denoise dynamic HP-

resultsSimulation results demonstrated an 8-fold increase in the calculated SNR of [1-

conclusionsSensitivity enhancement provided by this denoising significantly improved quantification of metabolite dynamics and could benefit future studies by improving image quality, enabling higher spatial resolution, and facilitating the extraction of metabolic information for clinical research.

Indexed as

BrainMagnetic Resonance ImagingAlgorithmsComputer SimulationHumansLactic AcidPyruvic AcidSignal-To-Noise RatioLactic AcidPyruvic Acidhigher-order singular value decompositionhyperpolarized C-13 pyruvateimage denoising

Identifiers

PMID34173268
PMCPMC8530853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.