Evidence map›Paper›PMID 34173226›Full record

ArticleJournal of periodontology2022

Gender differences in immunological response of African-American juveniles with Grade C molar incisor pattern periodontitis.

Tamara T Tavakoli, Fatemeh Gholami, Hong Huang, Patricia Furtado Gonçalves, Alejandro Villasante-Tezanos, Ikramuddin Aukhil, Rubelisa C G de Oliveira, Niki Hovencamp, Shannon Wallet, Efthimia Ioannidou and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  11. CD18 Mediates Neutrophil Imperviousness to theFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Tamara T TavakoliNova Southeastern University, Fort Lauderdale, FL, USA.
Fatemeh GholamiNova Southeastern University, Fort Lauderdale, FL, USA.
Hong HuangDepartment of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.
Patricia Furtado GonçalvesDepartment of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.
Alejandro Villasante-TezanosDepartment of Preventive Medicine and Population Health, Office of Biostatistics, University of Texas Medical Branch, Galveston, TX, USA.
Ikramuddin AukhilDepartment of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.
Rubelisa C G de OliveiraDivision of Periodontology and Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA.
Niki HovencampDepartment of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.
Shannon WalletDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA.
Efthimia IoannidouDivision of Oral and Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
Luciana M ShaddoxDepartment of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.
University of Florida · USFlorida College · USNova Southeastern University · USUniversity of Kentucky · USThe University of Texas Medical Branch at Galveston · USUniversity of North Carolina at Chapel Hill · US

Funding

Mechanisms and Treatment Response of Aggressive Periodontitis in ChildrenR01DE019456 · NIDCR · UNIVERSITY OF FLORIDA · PI AUKHIL, IKRAMUDDIN, SHADDOX, LUCIANA MACCHION · 2009 to 2018
$5.6M
NIDCR NIH HHS R01 DE019456
6 · The paper itself

Abstract

backgroundPrevalence of Grade C molar incisor periodontitis (C/MIP) in females (F) and males (M) is controversial, although some studies suggest higher prevalence in females. The objective of this study was to evaluate differences in clinical parameters, and levels of cyto/chemokines in gingival crevicular fluid (GCF) and peripheral blood response.

methodsGCF and blood were collected from 79 C/MIP African-American participants (53F and 26 M) and healthy controls (58F and 38 M), aged 5 to 23. Blood was stimulated with ultrapure LPS from Escherichia coli (Ec) and Porphyromonas gingivalis (Pg) and we quantified levels of 14 cyto/chemokines. Clinical parameters were collected before and 12 months following treatment

resultsNo clinical parameters or age differences were found between males and females, although age was negatively correlated with response to treatment. GCF levels of TNFα, IFNγ, MIP1α, and MCP1 from diseased and sites and healthy sites IFNγ levels were higher in M (P < 0.05). C/MIP females presented higher Pg and Ec LPS induced levels of Eotaxin, IFNγ, and GMCSF (P < 0.05), whereas healthy males presented higher Ec LPS induced levels of Eotaxin and IFNγ (P < 0.05). Inflammatory profiles were also different among genders in disease (P = 0.004).

conclusionsAlthough males seemed to present few elevated inflammatory markers in the GCF in disease and in health, females presented an elevated systemic inflammatory response to LPS in disease, which indicates a possible differential susceptibility to inflammation. Future studies need to determine if sex hormones have a role in the peripheral host response and in the pathogenesis of C/MIP.

Indexed as

Dental Enamel HypoplasiaPeriodontitisBlack or African AmericanChemokinesFemaleGingival Crevicular FluidHumansLipopolysaccharidesMalePorphyromonas gingivalisSex FactorsChemokinesLipopolysaccharidesactive immune responseaggressive periodontitiscytokinesepidemiologytherapy

Identifiers

PMID34173226
PMCPMC8709874
OpenAlexW3175797733

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.