Evidence map›Paper›PMID 34173155›Full record

ArticleBiological trace element research2022

Activated Nrf-2 Pathway by Vitamin E to Attenuate Testicular Injuries of Rats with Sub-chronic Cadmium Exposure.

Zhuo Chen, Zhicai Zuo, Kejie Chen, Zhuangzhi Yang, Fengyuan Wang, Jing Fang, Hengmin Cui, Hongrui Guo, Ping Ouyang, Zhengli Chen and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Protective effect ofOpen veterinary journal · 2026
    Article
  3. Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Zhuo Chen *College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.
Zhicai Zuo *College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.
Kejie Chen *School of Public Health, Chengdu Medical College, Chengdu, Sichuan, 610500, People's Republic of China.
Zhuangzhi Yang *Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, Sichuan, 611130, People's Republic of China.
Fengyuan Wang *College of Animal Science and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, 610041, People's Republic of China.
Jing FangCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China. fangjing4109@163.com.ORCID http://orcid.org/0000-0001-8593-378X
Hengmin CuiCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.
Hongrui GuoCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.
Ping OuyangCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.
Zhengli ChenCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.
Chao HuangCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.
Yi GengCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.
Wentao LiuCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.
Huidan DengCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.
Sichuan Agricultural University · CNChengdu Academy of Agriculture and Forestry Sciences · CNChengdu Medical College · CNSouthwest Minzu University · CN

Funding

National key research and development project 2018YFD0501800Sichuan beef cattle innovation team of National modern agricultural industry technology system SCCXTD-2020-13Sichuan Province Science and Technology Support Program 2018NZ0002,2019YFQ0012
6 · The paper itself

Abstract

Cadmium (Cd), a heavy metal element, cumulates in the testis and can cause male reproductive toxicity. Although vitamin E (VE) as one of potential antioxidants protects the testis against toxicity of Cd, the underlying mechanism remained uncompleted clear. The aim of this study was to investigate whether the Nrf-2 pathway is involved with the protective effect of VE on testicular damages caused by sub-chronic Cd exposure. Thirty-two SD rats were divided into four groups and orally administrated with VE and/or Cd for 28 consecutive days: control group, VE group (100 mg VE/kg), Cd group (5 mg CdCl

Indexed as

CadmiumVitamin EAnimalsAntioxidantsMaleOxidative StressRatsRats, Sprague-DawleySpermatozoaTestisAntioxidantsCadmiumVitamin ECadmiumNrf-2 pathwayOxidative stressSperm analysisTesticular histopathologyVitamin E

Identifiers

PMID34173155
OpenAlexW3174388768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.