Evidence map›Paper›PMID 34173092›Full record

ArticleBulletin of experimental biology and medicine2021

Association of Gene Polymorphisms of Some Endothelial Factors with Stent Reendothelization after Elective Coronary Artery Revascularization.

K B Timizheva, M M Azova, A Ait Aissa, A V Aghajanyan, L V Tskhovrebova, M L Blagonravov

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Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

K B TimizhevaPeoples' Friendship University of Russia (RUDN University), Moscow, Russia. kalima.bogatyreva@mail.ru.
M M AzovaPeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
A Ait AissaPeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
A V AghajanyanPeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
L V TskhovrebovaPeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
M L BlagonravovPeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Peoples' Friendship University of Russia · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Restenosis remains the main complication after percutaneous coronary interventions in patients with coronary heart disease. The causes of its development include, in particular, genetic factors. We studied polymorphic loci of genes encoding endothelin-1 (EDN1 rs5370), endothelin-1 receptor (EDNRA rs5333), endothelin-converting enzyme (ECE1 rs1076669), and endothelial NO synthase (eNOS rs1549758, eNOS rs1799983, and eNOS rs2070244) in the context of in-stent restenosis development. It was found that the analyzed polymorphisms of the endothelin system genes were more significant for patients aged ≥ 65 years, while the polymorphic loci of the endothelial NO synthase gene (eNOS rs1799983 and eNOS rs1549758) were predominantly associated with time of in-stent restenosis. The obtained results can be useful for comprehensive assessment of the restenosis risk factors and the choice of optimal treatment for patients with coronary heart disease before elective surgical intervention.

Indexed as

Coronary Artery DiseaseAgedAged, 80 and overCase-Control StudiesCoronary VesselsEndothelin-1Endothelin-Converting EnzymesEndothelium, VascularFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeGraft Occlusion, VascularHumansMaleECE1 protein, humanEndothelin-1Endothelin-Converting EnzymesNitric Oxide Synthase Type IIINOS3 protein, humanReceptor, Endothelin Aendotheliumgene polymorphismspercutaneous coronary interventionsrestenosis

Identifiers

PMID34173092
OpenAlexW3131927112

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.