Evidence map›Paper›PMID 34173088›Full record

ArticleAnnals of biomedical engineering2021

Ultrasound Triggered Drug Release from Affinity-Based β-Cyclodextrin Polymers for Infection Control.

Smriti Bohara, Nathan Rohner, Emily Budziszewski, Jackrit Suthakorn, Horst A von Recum, Agata A Exner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Smriti BoharaDepartment of Biomedical Engineering, Mahidol University, Salaya, Thailand.ORCID http://orcid.org/0000-0003-0454-8332
Nathan RohnerDepartment of Biomedical Engineering, Case Western Reserve University (CWRU), 10900 Euclid Avenue, Cleveland, OH, 44106-7207, USA.
Emily BudziszewskiDepartment of Radiology, Case Western Reserve University (CWRU), 10900 Euclid Avenue, Cleveland, OH, 44106-5056, USA.
Jackrit SuthakornDepartment of Biomedical Engineering, Mahidol University, Salaya, Thailand.
Horst A von RecumDepartment of Biomedical Engineering, Case Western Reserve University (CWRU), 10900 Euclid Avenue, Cleveland, OH, 44106-7207, USA. horst.vonrecum@case.edu.
Agata A ExnerDepartment of Radiology, Case Western Reserve University (CWRU), 10900 Euclid Avenue, Cleveland, OH, 44106-5056, USA. agata.exner@case.edu.ORCID http://orcid.org/0000-0003-3913-7066
Case Western Reserve University · USMahidol University · TH

Funding

Improving Efficacy of Local Drug Delivery Using UltrasoundR21EB026324 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI EXNER, AGATA A, KOLIOS, MICHAEL · 2018 to 2019
$397k
DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRSR01EB002632 · NIBIB · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CHEN, WEI · 2003 to 2003
$349k
National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health R21EB02632 to AAENIBIB NIH HHS R01 EB002632NIBIB NIH HHS R21 EB026324
6 · The paper itself

Abstract

This work demonstrates a slow, sustained drug delivery system that provides on-demand delivery bursts through the application of pulsed therapeutic ultrasound (TUS). Insoluble β-cyclodextrin-polymer (pCD) disks were loaded with a saturated antibiotic solution of rifampicin (RIF) and used for drug delivery studies. To obtain on-demand release from the implants, TUS was applied at an intensity of 1.8 W/cm

Indexed as

Drug LiberationUltrasonic WavesAnti-Bacterial Agentsbeta-CyclodextrinsInfection ControlPolymersRifampinAnti-Bacterial Agentsbeta-CyclodextrinsPolymersRifampinAffinity-based drug releaseCyclodextrin polymerRifampicinSurgical infectionTherapeutic ultrasound

Identifiers

PMID34173088
PMCPMC8458245
OpenAlexW3177000301

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.