Evidence map›Paper›PMID 34172951›Full record

ReviewNature reviews. Microbiology2021

Microbial production of advanced biofuels.

Jay Keasling, Hector Garcia Martin, Taek Soon Lee, Aindrila Mukhopadhyay, Steven W Singer, Eric Sundstrom

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Systematically Engineering for Efficient Production of 3-Methyl-1-Butanol in Escherichia coli.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Review
  8. Article
  9. Homoterpene Biosynthesis in Fungi.Angewandte Chemie (International ed. in English) · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Enhanced production of sabinene by engineered Saccharomyces cerevisiae from corn hydrolysates.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Secure biosystems design inApplied and environmental microbiology · 2025
    Article
  18. Article
  19. Article
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jay KeaslingJoint BioEnergy Institute, Emeryville, CA, USA. keasling@berkeley.edu.
Hector Garcia MartinJoint BioEnergy Institute, Emeryville, CA, USA.ORCID http://orcid.org/0000-0002-4556-9685
Taek Soon LeeJoint BioEnergy Institute, Emeryville, CA, USA.
Aindrila MukhopadhyayJoint BioEnergy Institute, Emeryville, CA, USA.ORCID http://orcid.org/0000-0002-6513-7425
Steven W SingerJoint BioEnergy Institute, Emeryville, CA, USA.
Eric SundstromBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Concerns over climate change have necessitated a rethinking of our transportation infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced by engineered microorganisms that use a renewable carbon source. Two biofuels, ethanol and biodiesel, have made inroads in displacing petroleum-based fuels, but their uptake has been limited by the amounts that can be used in conventional engines and by their cost. Advanced biofuels that mimic petroleum-based fuels are not limited by the amounts that can be used in existing transportation infrastructure but have had limited uptake due to costs. In this Review, we discuss engineering metabolic pathways to produce advanced biofuels, challenges with substrate and product toxicity with regard to host microorganisms and methods to engineer tolerance, and the use of functional genomics and machine learning approaches to produce advanced biofuels and prospects for reducing their costs.

Indexed as

BacteriaBiofuelsGenetic EngineeringGenomicsMachine LearningBiofuels

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.