Evidence map›Paper›PMID 34172937›Full record

ReviewNature reviews. Gastroenterology & hepatology2021

Defining comprehensive models of care for NAFLD.

Jeffrey V Lazarus, Quentin M Anstee, Hannes Hagström, Kenneth Cusi, Helena Cortez-Pinto, Henry E Mark, Michael Roden, Emmanuel A Tsochatzis, Vincent Wai-Sun Wong, Zobair M Younossi and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Diabetes and obesity reduce FIB-4 accuracy in MASLD referral pathways.JHEP reports : innovation in hepatology · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Assessing Clinician Engagement With a Passive Clinical Decision Support System for Liver Fibrosis Risk Stratification in a Weight Management Clinic.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025
    Article
  16. MetALD: New Perspectives on an Old Overlooked Disease.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  17. Review
  18. Review
  19. MetALD: Clinical aspects, pathophysiology and treatment.JHEP reports : innovation in hepatology · 2025
    Review
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jeffrey V LazarusBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain. jeffrey.lazarus@isglobal.org.ORCID http://orcid.org/0000-0001-9618-2299
Quentin M AnsteeTranslational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID http://orcid.org/0000-0002-9518-0088
Hannes HagströmKarolinska Institute, Stockholm, Sweden.
Kenneth CusiDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Veterans Health Administration and University of Florida, Gainesville, FL, United States.ORCID http://orcid.org/0000-0002-8629-418X
Helena Cortez-PintoClínica Universitária de Gastrenterologia, Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Henry E MarkEASL International Liver Foundation, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-8022-4279
Michael RodenDepartment of Endocrinology and Diabetology, Medical Faculty and University Hospital, Heinrich Heine University, Düsseldorf, Germany.ORCID http://orcid.org/0000-0001-8200-6382
Emmanuel A TsochatzisUniversity College London Institute for Liver and Digestive Health, Royal Free Hospital, London, United Kingdom.
Vincent Wai-Sun WongDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong.ORCID http://orcid.org/0000-0003-2215-9410
Zobair M YounossiCenter for Liver Diseases, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, VA, United States.
Shira Zelber-SagiUniversity of Haifa, Faculty of Social Welfare and Health Sciences, School of Public Health, Mount Carmel, Haifa, Israel.
Manuel Romero-Gómez *UCM Digestive Diseases, CIBEREHD and IBIS, Virgen del Rocío University Hospital, University of Seville, Seville, Spain. mromerogomez@us.es.ORCID http://orcid.org/0000-0001-8494-8947
Jörn M Schattenberg *Metabolic Liver Research Program, I. Department of Medicine, University Medical Centre Mainz, Mainz, Germany. joern.schattenberg@unimedizin-mainz.de.ORCID http://orcid.org/0000-0002-4224-4703

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease globally. Despite the increased demand placed on health-care systems, little attention has been given to the design and implementation of efficient and effective models of care for patients with NAFLD. In many health-care settings, no formal pathways exist and, where pathways are in place, they are often not standardized according to good practices. We systematically searched the peer-reviewed literature with the aim of identifying published examples of comprehensive models of care that answered four key questions: what services are provided? Where are they provided? Who is offering them? How are they coordinated and integrated within health-care systems? We identified seven models of care and synthesized the findings into eight recommendations nested within the 'what, where, who and how' of care models. These recommendations, aimed at policy-makers and practitioners designing and implementing models of care, can help to address the increasing need for the provision of good practice care for patients with NAFLD.

Indexed as

Practice Guidelines as TopicCritical PathwaysDelivery of Health CareDieteticsDisease ManagementGastroenterologyHumansNon-alcoholic Fatty Liver DiseaseNursingPatient Care TeamPhysical Therapy SpecialtyPolicy MakingPrimary Health Care

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.