Evidence map›Paper›PMID 34172832›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2021

Genetic loss-of-function of activating transcription factor 3 but not C-type lectin member 5A prevents diabetic peripheral neuropathy.

Hung-Wei Kan, Chin-Hong Chang, Ying-Shuang Chang, Yi-Ting Ko, Yu-Lin Hsieh

Open access · hybridAbstract read
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  8. The Antinociceptive Potential ofAntioxidants (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Hung-Wei Kan *School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Chin-Hong Chang *Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
Ying-Shuang ChangDepartment of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yi-Ting KoDepartment of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yu-Lin HsiehDepartment of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. ylhsieh@kmu.edu.tw.ORCID 0000-0002-6380-3455
Kaohsiung Medical University · TWChi Mei Medical Center · TWI-Shou University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the mediating roles of activating transcription factor 3 (ATF3), an injury marker, or C-type lectin member 5A (CLEC5A), an inflammatory response molecule, in the induction of endoplasmic reticulum (ER) stress and neuroinflammation in diabetic peripheral neuropathy in ATF3 and CLEC5A genetic knockout (aft3

Indexed as

Diabetic NeuropathiesActivating Transcription Factor 3AnimalsCytokinesEndoplasmic Reticulum StressLectins, C-TypeLoss of Function MutationMiceMice, Inbred C57BLReactive Oxygen SpeciesReceptors, Cell SurfaceActivating Transcription Factor 3Atf3 protein, mouseClec5a protein, mouseCytokinesLectins, C-TypeReactive Oxygen SpeciesReceptors, Cell Surface

Identifiers

PMID34172832
PMCPMC8440213
OpenAlexW3173950589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.