ArticleCommunications biology2021
SPX-related genes regulate phosphorus homeostasis in the marine phytoplankton, Phaeodactylum tricornutum.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- A plasma membrane Ca2+-dependent protein kinase PtCDPK2 promotes phosphorus starvation resilience in Phaeodactylum tricornutum.Journal of experimental botany · 2026Article
- Phosphorus Loading Drives Microalgal Community Changes and Enhances Nutrient Removal in Photobioreactors Treating Synthetic Wastewater.Plants (Basel, Switzerland) · 2026Article
- A Genome-Wide Association Study Reveals QTLs and Candidate Genes Associated with the Carotenoid Content in the Flesh ofAntioxidants (Basel, Switzerland) · 2025Article
- Nitrogen status exerts dynamic control over phosphorus sensing and acquisition via PSR1 in colimited marine diatoms.Science advances · 2025Article
- Widespread Presence of SPX and Its Potential Role as a Phosphorus Nutrient Regulator in Dinoflagellates.Microorganisms · 2025Article
- Remodeling of the terpenoid metabolism during prolonged phosphate depletion in the marine diatom Phaeodactylum tricornutum.Journal of phycology · 2025Article
- Transcriptomic response of marine dinoflagellate Prorocentrum cordatum to phosphorus deficiency.Scientific reports · 2025Article
- Crossed wires: diatom phosphate sensing mechanisms coordinate nitrogen metabolism.Plant signaling & behavior · 2024Article
- Physiological and Transcriptional Responses to Phosphorus Deficiency and Glucose-6-Phosphate Supplementation inInternational journal of molecular sciences · 2024Article
- Improving Lipid Content in the DiatomCurrent issues in molecular biology · 2024Article
- Effects and mechanisms of glyphosate as phosphorus nutrient on element stoichiometry and metabolism in the diatomApplied and environmental microbiology · 2024Article
- Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR-Associated Protein and Its Utility All at Sea: Status, Challenges, and Prospects.Microorganisms · 2024Review
- Two-sided effects of the organic phosphorus phytate on a globally important marine coccolithophorid phytoplankton.Microbiology spectrum · 2023Article
- Phosphorus deficiency induces sexual reproduction in the dinoflagellate Prorocentrum cordatum.Scientific reports · 2023Article
- Mechanistic basis for mitigating drought tolerance by selenium application in tobacco (Frontiers in plant science · 2023Article
- Trypsin is a coordinate regulator of N and P nutrients in marine phytoplankton.Nature communications · 2022Article
- Plant phosphate nutrition: sensing the stress.Stress biology · 2022Review
- Phytate as a Phosphorus Nutrient with Impacts on Iron Stress-Related Gene Expression for Phytoplankton: Insights from the DiatomApplied and environmental microbiology · 2022Article
- Unraveling the metabolic effects of benzophenone-3 on the endosymbiotic dinoflagellateFrontiers in microbiology · 2022Article
- RNA-seq analysis reveals genes related to photosynthetic carbon partitioning and lipid production inFrontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphorus (P) is an essential nutrient for marine phytoplankton. Maintaining intracellular P homeostasis against environmental P variability is critical for phytoplankton, but how they achieve this is poorly understood. Here we identify a SPX gene and investigate its role in Phaeodactylum tricornutum. SPX knockout led to significant increases in the expression of phosphate transporters, alkaline phosphatases (the P acquisition machinery) and phospholipid hydrolases (a mechanism to reduce P demand). These demonstrate that SPX is a negative regulator of both P uptake and P-stress responses. Furthermore, we show that SPX regulation of P uptake and metabolism involves a phosphate starvation response regulator (PHR) as an intermediate. Additionally, we find the SPX related genes exist and operate across the phytoplankton phylogenetic spectrum and in the global oceans, indicating its universal importance in marine phytoplankton. This study lays a foundation for better understanding phytoplankton adaptation to P variability in the future changing oceans.
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