ArticleScientific reports2021
Exposures associated with the onset of Kawasaki disease in infancy from the Japan Environment and Children's Study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Fertility Treatments and the Risk of Kawasaki Disease Among Offspring.JAMA network open · 2026Article
- Prenatal and postnatal risk factors associated with Kawasaki disease up to 3 years of age.Scientific reports · 2026Article
- An Update on Kawasaki Disease.Current rheumatology reports · 2024Review
- Association between maternal heavy metal exposure and Kawasaki Disease, the Japan Environment and Children's Study (JECS).Scientific reports · 2024Article
- The etiologies of Kawasaki disease.The Journal of clinical investigation · 2024Review
- Influence of H19 polymorphisms on breast cancer: risk assessment and prognostic implications via LincRNA H19/miR-675 and downstream pathways.Frontiers in oncology · 2024Article
- Maternal Serum Folic Acid Levels and Onset of Kawasaki Disease in Offspring During Infancy.JAMA network open · 2023Article
- Evaluating the time-varying risk of hypertension, cardiac events, and mortality following Kawasaki disease diagnosis.Pediatric research · 2023Article
- Evaluation of the association of birth order and group childcare attendance with Kawasaki disease using data from a nationwide longitudinal survey.Frontiers in pediatrics · 2023Article
- An Unintended Consequence of Pandemic Control Measures: Fewer Cases of Kawasaki Disease.The Journal of pediatrics · 2021Article
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Authors and funding
6 authors at 17 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kawasaki disease (KD) is an acute systemic vasculitis that mainly affects infants and young children. The etiology of KD has been discussed for several decades; however, no reproducible risk factors have yet been proven. We used the Japan Environment and Children's Study data to explore the association between the causal effects of exposure during the fetal and neonatal periods and KD onset. The Japan Environment and Children's Study, a nationwide birth cohort study, has followed approximately 100,000 children since 2011. We obtained data on exposures and outcomes from the first trimester to 12 months after birth. Finally, we included 90,486 children who were followed for 12 months. Among them, 343 children developed KD. Multivariate logistic regression revealed that insufficient intake of folic acid during pregnancy (odds ratio [OR], 1.37; 95% CI 1.08-1.74), maternal thyroid disease during pregnancy (OR, 2.03; 95% CI 1.04-3.94), and presence of siblings (OR, 1.33; 95% CI 1.06-1.67) were associated with KD onset in infancy. In this study, we identified three exposures as risk factors for KD. Further well-designed studies are needed to confirm a causal relationship between these exposures and KD onset.
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