Evidence map›Paper›PMID 34172753›Full record

ArticleNature communications2021

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes.

Jiwen Li, Lin Pan, William G Pembroke, Jessica E Rexach, Marlesa I Godoy, Michael C Condro, Alvaro G Alvarado, Mineli Harteni, Yen-Wei Chen, Linsey Stiles and 7 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 2 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 2 syntheses or guidelines pooled it, 176 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Plasma Extracellular Vesicles from Glioblastoma Patients Affect Phenotype and Activate Receptor Tyrosine Kinases in Glioblastoma Cells.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2026
    Article
  6. A Role for Astrocyte Metabolism in Species-Specific Neuronal Development.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. LPS-induced inflammation differentially affects endogenous CaMolecular medicine (Cambridge, Mass.) · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Astrocytes as Therapeutic Targets in Neurodegenerative Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  20. Article

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Jiwen LiDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.ORCID 0000-0002-1332-4763
Lin PanDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
William G PembrokeDepartment of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Jessica E RexachDepartment of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Marlesa I GodoyDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.ORCID 0000-0002-7012-1612
Michael C CondroDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Alvaro G AlvaradoDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Mineli HarteniDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Yen-Wei ChenDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Linsey StilesDepartment of Endocrinology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.ORCID 0000-0002-1514-458X
Angela Y ChenDepartment of Obstetrics and Gynecology, University of California, Los Angeles, CA, USA.ORCID 0000-0002-2697-0385
Ina B WannerDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Steven A GoldmanCenter for Translational Neuromedicine and Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.
Daniel H GeschwindDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.ORCID 0000-0003-2896-3450
Harley I KornblumDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Ye ZhangDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA. yezhang@ucla.edu.ORCID 0000-0002-1546-5930
University of California, Los Angeles · USUCLA Health · USUniversity of Copenhagen · DK

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUSAN Y BOOKHEIMER · 2020 to 2026
$9.6M
Training Grant in Neurobehavioral GeneticsT32MH073526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GESCHWIND, DANIEL H · 2006 to 2020
$2.4M
TRANSCRIPTIONAL DETERMINANTS OF THE FATE TRAJECTORIES OF SINGLE HUMAN GLIAL PROGENITOR CELLS IN RESPONSE TO DEMYELINATION IN VIVOR01NS110776 · NINDS · UNIVERSITY OF ROCHESTER · PI GOLDMAN, STEVEN ALAN · 2019 to 2023
$1.8M
Molecular characterization of reactive astrocytes in humansR01NS109025 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, YE · 2018 to 2022
$1.7M
Single cell and tissue level functional genomic analysis of astrocyte-related mechanisms in tauopathyK08NS105916 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REXACH, JESSICA E · 2019 to 2023
$1.1M
Identification of transcription factors that regulate astrocyte differentiationR00NS089780 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, YE · 2017 to 2019
$745k
Identification of candidate juvenile protective factors in neuron, glia, and vascular cells of human and mouse brainR03AG065772 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, YE · 2020 to 2021
$306k
NCATS NIH HHS UL1 TR001881NIA NIH HHS R03 AG065772NICHD NIH HHS P50 HD103557NIMH NIH HHS T32 MH073526NINDS NIH HHS K08 NS105916NINDS NIH HHS R00 NS089780NINDS NIH HHS R01 NS109025NINDS NIH HHS R01 NS110776
6 · The paper itself

Abstract

Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse models and the similarities and differences between human and mouse astrocytes are insufficiently characterized, presenting a barrier in translational research. Based on analyses of acutely purified astrocytes, serum-free cultures of primary astrocytes, and xenografted chimeric mice, we find extensive conservation in astrocytic gene expression between human and mouse samples. However, the genes involved in defense response and metabolism show species-specific differences. Human astrocytes exhibit greater susceptibility to oxidative stress than mouse astrocytes, due to differences in mitochondrial physiology and detoxification pathways. In addition, we find that mouse but not human astrocytes activate a molecular program for neural repair under hypoxia, whereas human but not mouse astrocytes activate the antigen presentation pathway under inflammatory conditions. Here, we show species-dependent properties of astrocytes, which can be informative for improving translation from mouse models to humans.

Indexed as

AnimalsAntigen PresentationAstrocytesCells, CulturedGene ExpressionHumansInactivation, MetabolicInflammationMiceMitochondriaNervous System DiseasesOxidative StressPoly I-CSpecies SpecificityTranscriptomeTumor Necrosis Factor-alphaPoly I-CTumor Necrosis Factor-alpha

Identifiers

PMID34172753
PMCPMC8233314
OpenAlexW3173720709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.