ArticleNature communications2021
Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Biofilm-Antagonist Ginger-Based 3D-Printable Photoresins for Complex Implant Designs Exhibiting Advanced Multifunctional Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Advanced Macromolecular Architectures via Inorganic Polymers.Macromolecular rapid communications · 2026Review
- Applications of a continuum model for brush gels.International journal of solids and structures · 2026Article
- Injectable Hydrogels with Tissue-Adaptive Gelation and Mechanical Properties: Enhancing Softness and Stability.Gels (Basel, Switzerland) · 2025Article
- Damage-resistant and body-temperature shape memory skin-mimic elastomer for biomedical applications.Science advances · 2025Article
- Polymerizable Cholinium-Based Antibiotics for Polymer Carriers: Systems with Combined Load of Cloxacillin and Ampicillin.Molecules (Basel, Switzerland) · 2024Article
- Revealing Long-Range Order in Brush-like Graft Copolymers Through In Situ Measurements of X-Ray Scattering During Deformation.Polymers · 2024Article
- Carbosiloxane Bottlebrush Networks for Enhanced Performance and Recyclability.Macromolecules · 2024Article
- Regulation of Hard Segment Cluster Structures for High-performance Poly(urethane-urea) Elastomers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Bottlebrush Networks: A Primer for Advanced Architectures.Angewandte Chemie (International ed. in English) · 2024Review
- Programming and Reprogramming the Viscoelasticity and Magnetic Response of Magnetoactive Thermoplastic Elastomers.Polymers · 2023Article
- Heterotelechelic Silicones: Facile Synthesis and Functionalization Using Silane-Based Initiators.Macromolecules · 2023Article
- 3D printable soft and solvent-free thermoplastic elastomer containing dangling bottlebrush chains.Materials advances · 2023Article
- Bioadhesive polymer semiconductors and transistors for intimate biointerfaces.Science (New York, N.Y.) · 2023Article
- Tissue Reaction to Low-Density Polyacrylamide Gel as a Carrier for Microimplants in the Adipose Fin of Rainbow Trout.Gels (Basel, Switzerland) · 2023Article
- Conductive and elastic bottlebrush elastomers for ultrasoft electronics.Nature communications · 2023Article
- Article
- Injectable bottlebrush hydrogels with tissue-mimetic mechanical properties.Science advances · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Current materials used in biomedical devices do not match tissue's mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.