ArticleBDJ open2021
Clinical efficacy of nanohydroxyapatite-containing toothpaste at relieving dentin hypersensitivity: an 8 weeks randomized control trial.
Article in BDJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Clinical outcome of Nd:YAG laser and bioactive glass combined use for dentin hypersensitivity after scaling and root planning: a short-term comparative study.European journal of medical research · 2025Trial
- Intrapulpal thermal variation in standalone and dentifrice-assisted laser desensitisation at two time intervals.BMC oral health · 2026Article
- Article
- Dentin hypersensitivity, an enigma revisited: Mechanisms, diagnosis and therapeutic advances.Journal of conservative dentistry and endodontics · 2026Review
- The Impact of Calcination on the Structure, Bioactivity, and Biocompatibility of Sol-Gel-Derived Glasses.ACS omega · 2025Article
- Advancements in nanohydroxyapatite: synthesis, biomedical applications and composite developments.Regenerative biomaterials · 2025Review
- Review
- Nanohydroxyapatite in dentistry: A comprehensive review.The Saudi dental journal · 2023Article
- Improving Oral Health with Fluoride-Free Calcium-Phosphate-Based Biomimetic Toothpastes: An Update of the Clinical Evidence.Biomimetics (Basel, Switzerland) · 2023Review
- Evaluation of Bioactive Glass Treatment for Dentin Hypersensitivity: A Systematic Review.Biomedicines · 2023Review
- The Effectiveness of Calcium Phosphates in the Treatment of Dentinal Hypersensitivity: A Systematic Review.Bioengineering (Basel, Switzerland) · 2023Review
- Tooth Whitening with Hydroxyapatite: A Systematic Review.Dentistry journal · 2023Review
- Clinical Evidence of Biomimetic Hydroxyapatite in Oral Care Products for Reducing Dentin Hypersensitivity: An Updated Systematic Review and Meta-Analysis.Biomimetics (Basel, Switzerland) · 2023Review
- Remineralization of molar incisor hypomineralization (MIH) with a hydroxyapatite toothpaste: an in-situ study.BDJ open · 2022Article
- Nano-Hydroxyapatite (nHAp) in the Remineralization of Early Dental Caries: A Scoping Review.International journal of environmental research and public health · 2022Article
- BDJ Open 2021 - our most successful year to date.British dental journal · 2022Article
- Comparative Study of Anti-COVID Mouthwash and Remineralization Agents on Dentinal Tubular Occlusion: AnJournal of International Society of Preventive & Community DentistryArticle
- Efficacy of advanced treatment modalities of dentin hypersensitivity: A systematic review and meta-analysis.Journal of oral biology and craniofacial researchReview
- Morphological & chemo mechanical analysis of exposed cervical dentin treated with three different desensitizing pastes (comparative in vitro study).Journal of oral biology and craniofacial researchArticle
- Six-month follow-up of salivary antioxidant defense outcomes of individuals using medicated toothpaste.Journal of conservative dentistry : JCDArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to investigate and compare the effectiveness of several toothpastes containing nanohydroxyapatite (nano-HAP) to relieve dentin hypersensitivity (DHS) with that of a commercial desensitizing dentifrice containing calcium sodium phosphosilicate (CSPS). MATERIALS AND
methodsIn this double-blind, randomized, parallel-group clinical trial, patients diagnosed with DHS and qualified to participate were randomized into four groups: toothpaste containing 10% nano-HAP (10%nano-HAP), 15% nano-HAP (15%nano-HAP), 10% nano-HAP supplemented with potassium nitrate (KNO
resultsWith either air or cold stimulus, VAS indicated a significant (P < 0.001) reduction from baseline DHS at each time point with all test toothpastes. Among the nano-HAP toothpastes, 15%nano-HAP and 10%nano-HAPKN were consistent in DHS reduction with both stimuli. With either stimuli, the CSPS did not significantly differ from 15%nano-HAP and 10%nano-HAPKN at any time point.
conclusionsToothpaste containing nano-HAP (10 or 15%) alone or supplemented with KNO
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.