Evidence map›Paper›PMID 34172567›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

APPsα rescues impaired Ca

Susann Ludewig, Ulrike Herrmann, Kristin Michaelsen-Preusse, Kristin Metzdorf, Jennifer Just, Charlotte Bold, Ulrike C Müller, Martin Korte

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. APPsα Rescues Tau-Induced Synaptic Pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  3. Spatial and Functional Crosstalk between the Mitochondrial NaInternational journal of molecular sciences · 2022
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Susann LudewigDepartment of Cellular Neurobiology Zoological Institute, Technische Universität Braunschweig, 38106 Braunschweig, Germany.
Ulrike HerrmannDepartment of Cellular Neurobiology Zoological Institute, Technische Universität Braunschweig, 38106 Braunschweig, Germany.
Kristin Michaelsen-PreusseDepartment of Cellular Neurobiology Zoological Institute, Technische Universität Braunschweig, 38106 Braunschweig, Germany.ORCID 0000-0002-7838-5882
Kristin MetzdorfDepartment of Cellular Neurobiology Zoological Institute, Technische Universität Braunschweig, 38106 Braunschweig, Germany.
Jennifer JustDepartment of Cellular Neurobiology Zoological Institute, Technische Universität Braunschweig, 38106 Braunschweig, Germany.ORCID 0000-0003-4646-6458
Charlotte BoldDepartment of Functional Genomics, Institute for Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-2335-7403
Ulrike C MüllerDepartment of Functional Genomics, Institute for Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-0587-2575
Martin KorteDepartment of Cellular Neurobiology Zoological Institute, Technische Universität Braunschweig, 38106 Braunschweig, Germany; m.korte@tu-bs.de.ORCID 0000-0001-6956-5913
Helmholtz Centre for Infection Research · DETechnische Universität Braunschweig · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in Ca

Indexed as

HomeostasisAmyloid beta-Protein PrecursorAnimalsCalciumCytosolEndoplasmic ReticulumExcitatory Postsynaptic PotentialsHippocampusIntegrasesLong-Term PotentiationMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalNeuronsSarcoplasmic Reticulum Calcium-Transporting ATPasesAmyloid beta-Protein PrecursorAplp2 protein, mouseCalciumCre recombinaseIntegrasesSarcoplasmic Reticulum Calcium-Transporting ATPasesAlzheimer’s diseaseAPPCa2+ homeostasissynaptic plasticity

Identifiers

PMID34172567
PMCPMC8256088
OpenAlexW3175232045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.