ArticleProceedings of the National Academy of Sciences of the United States of America2021
Serial sarcomere number is substantially decreased within the paretic biceps brachii in individuals with chronic hemiparetic stroke.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Motor rehabilitation after stroke: European Stroke Organisation (ESO) consensus-based definition and guiding framework.European stroke journal · 2023Guideline
- Elucidation of Architectural and Compositional Factors Associated With Inter-Individual Variability in Passive Shear Modulus of the Human Vastus Lateralis in Young Healthy Males.Scandinavian journal of medicine & science in sports · 2026Article
- In Vivo Long Head of the Biceps Tendon Stiffness Varies with Forearm Position During Active Contraction: Implications for Personalized Rehabilitation After SLAP Lesions.Journal of personalized medicine · 2026Article
- Review
- Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture.The Journal of general physiology · 2026Article
- Relationship of lower-limb muscle properties with motor control, walking and balance in stroke survivors.Scientific reports · 2025Article
- Minimal changes in excitation-contraction coupling in spastic human muscle.Journal of neurophysiology · 2025Article
- Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolongedbioRxiv : the preprint server for biology · 2025Article
- Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats.Skeletal muscle · 2024Article
- Stroke-induced excess in capillarization relative to oxidative capacity in rats is muscle specific.Physiological reports · 2024Article
- Collagen architecture and biomechanics of gracilis and adductor longus muscles from children with cerebral palsy.The Journal of physiology · 2024Article
- Sensitivity analyses of probabilistic and deterministic DTI tractography methodologies for studying arm muscle architecture.Magnetic resonance in medicine · 2024Article
- Article
- Ultrasonographic measurements of fascicle length overestimate adaptations in serial sarcomere number.Experimental physiology · 2023Article
- Unique morphological architecture of the hamstring muscles and its functional relevance revealed by analysis of isolated muscle specimens and quantification of structural parameters.Journal of anatomy · 2023Article
- Multi-sweep 3-dimensional ultrasound is accurate for in vivo muscle volume quantification, expanding use to larger muscles.Journal of biomechanics · 2023Article
- Brachial plexus birth injury and cerebral palsy lead to a common contracture phenotype characterized by reduced functional muscle length and strength.Frontiers in rehabilitation sciences · 2022Article
- Development of DTI Based Probabilistic Tractography Methods to Characterize Arm Muscle Architecture in Individuals Post Hemiparetic Stroke.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- In vivo non-invasive near-infrared spectroscopy distinguishes normal, post-stroke, and botulinum toxin treated human muscles.Scientific reports · 2021Article
- Changes in muscle-tendon unit length-force characteristics following experimentally induced photothrombotic stroke cannot be explained by changes in muscle belly structure.European journal of applied physiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A muscle's structure, or architecture, is indicative of its function and is plastic; changes in input to or use of the muscle alter its architecture. Stroke-induced neural deficits substantially alter both input to and usage of individual muscles. We combined in vivo imaging methods (second-harmonic generation microendoscopy, extended field-of-view ultrasound, and fat-suppression MRI) to quantify functionally meaningful architecture parameters in the biceps brachii of both limbs of individuals with chronic hemiparetic stroke and in age-matched, unimpaired controls. Specifically, serial sarcomere number (SSN) and physiological cross-sectional area (PCSA) were calculated from data collected at three anatomical scales: sarcomere length, fascicle length, and muscle volume. The interlimb differences in SSN and PCSA were significantly larger for stroke participants than for participants without stroke (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.