ArticleNeurology2021
Domain-Specific Outcomes for Stroke Clinical Trials: What the Modified Rankin Isn't Ranking.
Abstract read
In one paragraph
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence, Trajectory, and Factors Associated With Patient-Reported Nonmotor Outcomes After Stroke: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- The relevance of rich club regions for functional outcome post-stroke is enhanced in women.Human brain mapping · 2023Trial
- Extension of the FUNC Score for Prediction of 12-Month Functional Independence after Primary Intracerebral Hemorrhage.Neurocritical care · 2026Article
- Association of C-Reactive Protein with Functional Outcome After Acute Ischemic Stroke Across TOAST Subtypes.Journal of clinical medicine · 2026Article
- Major Adverse Cognitive Events (MACE-Cog): A New "MACE" Framework for Cognitive Outcomes in Cardiovascular Diseases and Stroke.Circulation · 2026Review
- A scoping review of outcome and outcome measure sets for adults with spinal cord injury, stroke, and traumatic brain injury.Journal of rehabilitation medicine · 2026Article
- Association between elevated adiponectin levels and 5-year risk of clinical outcomes in patients with ischaemic stroke.Stroke and vascular neurology · 2026Observational
- Patient-reported non-motor outcomes after endovascular thrombectomy and intravenous thrombolysis: an observational study.European stroke journal · 2026Observational
- Genomic insights into stroke recovery: cross-phenotype associations.Brain communications · 2026Article
- Health-Related Quality of Life in Survivors of Stroke Post Inpatient Rehabilitation Discharged to a Home Setting.Archives of rehabilitation research and clinical translation · 2025Article
- Artifical intelligence-powered delta-NIHSS-based model for predicting recurrence, disability and mortality after acute ischaemic strokes (DISCO): a modelling study.EClinicalMedicine · 2025Article
- West Nile Virus Neuroinvasive Disease in Patients Treated With Anti-CD20 Therapies.Neurology. Clinical practice · 2025Article
- Article
- Association Between Changes in White Matter Volume Detected With Diffusion Tensor-Based Morphometry and Motor Recovery After Stroke.Neurology · 2025Article
- Evaluation of the Prevalence of Sleep Disorders and Their Association with Stroke: A Hospital-Based Retrospective Study.Journal of clinical medicine · 2025Article
- Standardizing Domains and Metrics of Stroke Recovery: A Systematic Review.Brain sciences · 2024Review
- Prospective evaluation of the relationship between cognition and recovery outcomes after cardiac arrest.Resuscitation · 2024Article
- Article
- Disability and Recurrent Stroke Among Participants in Stroke Prevention Trials.JAMA network open · 2024Article
- Prevalence, patterns, and predictors of patient-reported non-motor outcomes at 30 days after acute stroke: Prospective observational hospital cohort study.International journal of stroke : official journal of the International Stroke Society · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Robynne G BraunFrom the Department of Neurology (R.G.B., J.W.C.), University of Maryland, Baltimore; Department of Emergency Medicine (L.H.), Washington University, St. Louis, MO; Department of Clinical Sciences, Lund (A.L.), Lund University; Department of Neurology (A.G.L.), Skåne University Hospital, Lund, Sweden; Departments of Neurology (A.d.H.) and Health and Kinesiology (J.A.D., K.R.L.), University of Utah, Salt Lake City; Department of Neurology (S.C.C.), University of California, Los Angeles; California Rehabilitation Institute (S.C.C.), Los Angeles; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville. robynne.braun@umm.edu.ORCID 0000-0002-3579-6665
Laura HeitschFrom the Department of Neurology (R.G.B., J.W.C.), University of Maryland, Baltimore; Department of Emergency Medicine (L.H.), Washington University, St. Louis, MO; Department of Clinical Sciences, Lund (A.L.), Lund University; Department of Neurology (A.G.L.), Skåne University Hospital, Lund, Sweden; Departments of Neurology (A.d.H.) and Health and Kinesiology (J.A.D., K.R.L.), University of Utah, Salt Lake City; Department of Neurology (S.C.C.), University of California, Los Angeles; California Rehabilitation Institute (S.C.C.), Los Angeles; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville.ORCID 0000-0002-8712-4123
John W ColeFrom the Department of Neurology (R.G.B., J.W.C.), University of Maryland, Baltimore; Department of Emergency Medicine (L.H.), Washington University, St. Louis, MO; Department of Clinical Sciences, Lund (A.L.), Lund University; Department of Neurology (A.G.L.), Skåne University Hospital, Lund, Sweden; Departments of Neurology (A.d.H.) and Health and Kinesiology (J.A.D., K.R.L.), University of Utah, Salt Lake City; Department of Neurology (S.C.C.), University of California, Los Angeles; California Rehabilitation Institute (S.C.C.), Los Angeles; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville.ORCID 0000-0001-9263-8930
Arne G LindgrenFrom the Department of Neurology (R.G.B., J.W.C.), University of Maryland, Baltimore; Department of Emergency Medicine (L.H.), Washington University, St. Louis, MO; Department of Clinical Sciences, Lund (A.L.), Lund University; Department of Neurology (A.G.L.), Skåne University Hospital, Lund, Sweden; Departments of Neurology (A.d.H.) and Health and Kinesiology (J.A.D., K.R.L.), University of Utah, Salt Lake City; Department of Neurology (S.C.C.), University of California, Los Angeles; California Rehabilitation Institute (S.C.C.), Los Angeles; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville.ORCID 0000-0003-1942-7330
Adam de HavenonFrom the Department of Neurology (R.G.B., J.W.C.), University of Maryland, Baltimore; Department of Emergency Medicine (L.H.), Washington University, St. Louis, MO; Department of Clinical Sciences, Lund (A.L.), Lund University; Department of Neurology (A.G.L.), Skåne University Hospital, Lund, Sweden; Departments of Neurology (A.d.H.) and Health and Kinesiology (J.A.D., K.R.L.), University of Utah, Salt Lake City; Department of Neurology (S.C.C.), University of California, Los Angeles; California Rehabilitation Institute (S.C.C.), Los Angeles; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville.ORCID 0000-0001-8178-8597
Jason A DudeFrom the Department of Neurology (R.G.B., J.W.C.), University of Maryland, Baltimore; Department of Emergency Medicine (L.H.), Washington University, St. Louis, MO; Department of Clinical Sciences, Lund (A.L.), Lund University; Department of Neurology (A.G.L.), Skåne University Hospital, Lund, Sweden; Departments of Neurology (A.d.H.) and Health and Kinesiology (J.A.D., K.R.L.), University of Utah, Salt Lake City; Department of Neurology (S.C.C.), University of California, Los Angeles; California Rehabilitation Institute (S.C.C.), Los Angeles; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville.ORCID 0000-0002-1783-7224
Keith R LohseFrom the Department of Neurology (R.G.B., J.W.C.), University of Maryland, Baltimore; Department of Emergency Medicine (L.H.), Washington University, St. Louis, MO; Department of Clinical Sciences, Lund (A.L.), Lund University; Department of Neurology (A.G.L.), Skåne University Hospital, Lund, Sweden; Departments of Neurology (A.d.H.) and Health and Kinesiology (J.A.D., K.R.L.), University of Utah, Salt Lake City; Department of Neurology (S.C.C.), University of California, Los Angeles; California Rehabilitation Institute (S.C.C.), Los Angeles; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville.ORCID 0000-0002-7643-3887
Steven C CramerFrom the Department of Neurology (R.G.B., J.W.C.), University of Maryland, Baltimore; Department of Emergency Medicine (L.H.), Washington University, St. Louis, MO; Department of Clinical Sciences, Lund (A.L.), Lund University; Department of Neurology (A.G.L.), Skåne University Hospital, Lund, Sweden; Departments of Neurology (A.d.H.) and Health and Kinesiology (J.A.D., K.R.L.), University of Utah, Salt Lake City; Department of Neurology (S.C.C.), University of California, Los Angeles; California Rehabilitation Institute (S.C.C.), Los Angeles; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville.ORCID 0000-0002-6214-6211
Bradford B WorrallFrom the Department of Neurology (R.G.B., J.W.C.), University of Maryland, Baltimore; Department of Emergency Medicine (L.H.), Washington University, St. Louis, MO; Department of Clinical Sciences, Lund (A.L.), Lund University; Department of Neurology (A.G.L.), Skåne University Hospital, Lund, Sweden; Departments of Neurology (A.d.H.) and Health and Kinesiology (J.A.D., K.R.L.), University of Utah, Salt Lake City; Department of Neurology (S.C.C.), University of California, Los Angeles; California Rehabilitation Institute (S.C.C.), Los Angeles; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville.ORCID 0000-0001-9386-4091
GPAS Collaboration, Phenotyping Core
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MNSTN National Clinical Coordinating CenterU01NS086872 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Pooja Khatri · 2013 to 2026
$32.3MInstitutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI PAPIN, JASON, WORRALL, BRADFORD B · 2019 to 2023
$3.9MNeurorehabilitation and Restorative Neuroscience NetworkK12HD093427 · NICHD · GEORGETOWN UNIVERSITY · PI BREGMAN, BARBARA S, DROMERICK, ALEXANDER W · 2017 to 2021
$3.9MBrain-computer interface-functional electrical stimulation for stroke recoveryR01HD095457 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CRAMER, STEVEN C., DO, AN · 2019 to 2023
$3.7MEFFECTIVENESS OF ROBOT-ASSISTED HAND MOVEMENT TRAINING AFTER STROKER01HD062744 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI David Jay Reinkensmeyer · 2010 to 2026
$3.5MStroke Central Atlantic Network for Research (SCANR)U24NS107222 · NINDS · MEDSTAR HEALTH RESEARCH INSTITUTE · PI Amie Hsia, Peter Ethan Turkeltaub · 2018 to 2026
$2.6MCNV And Stroke (CaNVAS)R01NS114045 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI COLE, JOHN W. · 2020 to 2024
$2.6MGenetic variation, stress, and functional outcomes after stroke rehabilitationR01NR015591 · NINR · UNIVERSITY OF CALIFORNIA-IRVINE · PI CRAMER, STEVEN C., HOLMAN, ELLEN ALISON · 2015 to 2020
$2.6MGENETICS OF EARLY NEUROLOGICAL INSTABILITY AFTER ISCHEMIC STROKE (GENISIS)K23NS099487 · NINDS · WASHINGTON UNIVERSITY · PI HEITSCH, LAURA · 2017 to 2021
$996kTreatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRIK23NS105924 · NINDS · YALE UNIVERSITY · PI DE HAVENON, ADAM H. · 2019 to 2023
$988kGastrointestinal Microbiome and Stroke Outcomes Network (GEMSTONE)R21NS106480 · NINDS · UNIVERSITY OF VIRGINIA · PI WORRALL, BRADFORD B · 2018 to 2019
$469kNCATS NIH HHS KL2 TR003016NCATS NIH HHS UL1 TR001863NICHD NIH HHS K12 HD093427NICHD NIH HHS R01 HD062744NICHD NIH HHS R01 HD095457NINDS NIH HHS K23 NS099487NINDS NIH HHS K23 NS105924NINDS NIH HHS R01 NS114045NINDS NIH HHS R21 NS106480NINDS NIH HHS U01 NS086872NINDS NIH HHS U24 NS107222NINR NIH HHS R01 NR015591
Abstract
Global outcome measures that are widely used in stroke clinical trials, such as the modified Rankin Scale (mRS), lack sufficient detail to detect changes within specific domains (e.g., sensory, motor, visual, linguistic, or cognitive function). Yet such data are vital for understanding stroke recovery and its mechanisms. Poststroke deficits in specific domains differ in their rate and degree of recovery and in their effects on overall independence and quality of life. For example, even in a patient with complete recovery of strength, persistent deficits in the nonmotor domains such as language and cognition may make a return to independent living impossible. In such cases, global measures based solely on the patient's degree of independence would overlook a complete recovery in the motor domain. Capturing these important aspects of recovery demands a domain-specific approach. If stroke outcomes trials are to incorporate finer-grained recovery metrics-which can require substantial time, effort, and expertise to implement-efficiency must be a priority. In this article, we discuss how commonly collected clinical data from the NIH Stroke Scale can guide the judicious selection of relevant recovery domains for more detailed testing. Our overarching goal is to make the implementation of domain-specific testing more feasible for large-scale clinical trials on stroke recovery.
Indexed as
Severity of Illness IndexStroke RehabilitationClinical Trials as TopicHumansOutcome Assessment, Health CarePractice Guidelines as TopicStroke
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What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.