Evidence map›Paper›PMID 34172346›Full record

ArticleThe Journal of arthroplasty2021

Google Trends Analysis Shows Increasing Public Interest in Platelet-Rich Plasma Injections for Hip and Knee Osteoarthritis.

Samuel A Cohen, Thompson Zhuang, Michelle Xiao, John B Michaud, Derek F Amanatullah, Robin N Kamal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of arthroplasty, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  8. Spin and reporting bias in the use of platelet-rich plasma for the treatment of knee osteoarthritis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samuel A CohenDepartment of Orthopaedic Surgery, Voices Health Policy Research Center, Stanford University, Redwood City, CA.
Thompson ZhuangDepartment of Orthopaedic Surgery, Voices Health Policy Research Center, Stanford University, Redwood City, CA.
Michelle XiaoDepartment of Orthopaedic Surgery, Voices Health Policy Research Center, Stanford University, Redwood City, CA.
John B MichaudDepartment of Orthopaedic Surgery, Voices Health Policy Research Center, Stanford University, Redwood City, CA.
Derek F AmanatullahDepartment of Orthopaedic Surgery, Voices Health Policy Research Center, Stanford University, Redwood City, CA.
Robin N KamalDepartment of Orthopaedic Surgery, Voices Health Policy Research Center, Stanford University, Redwood City, CA.

Funding

Institutional Career Development Core (KL2)KL2TR003143 · NCATS · STANFORD UNIVERSITY · PI ASCH, STEVEN M. · 2019 to 2023
$8.7M
Developing and Testing a Tool for Preference Elicitation in Carpal Tunnel SyndromeK23AR073307 · NIAMS · STANFORD UNIVERSITY · PI KAMAL, ROBIN N · 2018 to 2022
$866k
NCATS NIH HHS KL2 TR003143NIAMS NIH HHS K23 AR073307
6 · The paper itself

Abstract

backgroundOsteoarthritis is a chronic musculoskeletal condition that frequently affects the hip and knee joints. Given the burden associated with surgical intervention for hip and knee osteoarthritis, patients continue to search for potential nonoperative treatments. One biologic therapy with mixed clinical and basic science evidence for treating osteoarthritis is platelet-rich plasma injections into the affected joint. We used the Google Trends tool to provide a quantitative analysis of national interest in platelet-rich plasma injections for hip and knee osteoarthritis.

methodsGoogle Trends parameters were selected to obtain search data from January 2009 to December 2019. Various combinations of "arthritis," "osteoarthritis," "PRP," "platelet-rich plasma," "knee," and "hip" were entered into the Google Trends tool and trend analyses were performed.

resultsThree linear models were generated to display search volume trends in the United States for platelet-rich plasma and osteoarthritis, hip osteoarthritis, and knee osteoarthritis, respectively. All models showed increased Google queries as time progressed (P < .001), with R

conclusionOur results demonstrate a significant rise in Google queries related to platelet-rich plasma injections for osteoarthritis of the hip and knee since 2009. Surgeons treating hip and knee osteoarthritis patients can expect continued interest in platelet-rich plasma, despite inconclusive clinical and basic science data. Trends in public interest may inform patient counseling, shared decision-making, and directions for future clinical research.

Indexed as

Osteoarthritis, HipOsteoarthritis, KneePlatelet-Rich PlasmaHumansHyaluronic AcidInjections, Intra-ArticularSearch EngineTreatment OutcomeHyaluronic Acidgoogle trendshipkneeosteoarthritisplatelet-rich plasma (PRP)

Identifiers

PMID34172346
PMCPMC8478783

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.