ArticleBiological psychiatry2021
Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts.
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Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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31citing papers in PubMed, 4 pooled it
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Neural mechanisms of suicide thoughts and behaviors in major depressive disorder: abnormal regional brain activity and its functional connectivity.BMC psychiatry · 2025Pooled it
- Concurrent validity and reliability of suicide risk assessment instruments: A meta-analysis of 20 instruments across 27 international cohorts.Neuropsychology · 2023Pooled it
- Evidence for the biopsychosocial model of suicide: a review of whole person modeling studies using machine learning.Frontiers in psychiatry · 2023Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Brain Functional Network Alterations in Adolescents With Major Depressive Disorder and Suicidal Attempt: A Resting-State fMRI Study.Alpha psychiatry · 2026Article
- Differences in white matter structural networks in family risk of major depressive disorder and suicidality: A connectome analysis.Journal of affective disorders · 2026Article
- Article
- Causal Analyses of Associations Between Brain Structure and Suicide Attempt in Adulthood and Late Childhood.JAACAP open · 2025Article
- Brain Volume Reductions and Relationship With Depression and Cognitive Functioning in Suicide in Older Adults: A Cross-Sectional and Longitudinal Study Using Bayesian Multilevel Modeling.Biological psychiatry global open science · 2025Article
- Illuminating posterior targets for TMS beyond the prefrontal cortex.Nature. Mental health · 2025Article
- Psychoneuroimmunoendocrinological and neuroanatomical basis of suicidal behavior: potential therapeutic strategies with a focus on transcranial magnetic stimulation (TMS).Brain, behavior, & immunity - health · 2025Article
- Genetic Links Between Subcortical Brain Morphometry and Suicide Attempt Risk in Children and Adults.Human brain mapping · 2025Article
- Machine learning based identification of suicidal ideation using non-suicidal predictors in a university mental health clinic.Scientific reports · 2025Article
- 'Unravelling the shared genetic architecture between suicidality and subcortical brain volume: a genome-wide association study'.Acta neuropsychiatrica · 2025Article
- Suicidal risk is associated with hyper-connections in the frontal-parietal network in patients with depression.Translational psychiatry · 2025Article
- Structural brain changes in the anterior cingulate cortex of major depressive disorder individuals with suicidal ideation: Evidence from the REST-meta-MDD project.Psychological medicine · 2025Article
- Altered local gyrification index and corresponding functional connectivity in female depressed adolescents with suicide attempts and non-suicidal self-injury.Psychoradiology · 2025Article
- Revealing the Mechanism ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Article
Corrections and comments
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Authors and funding
64 authors at 20 institutions in 7 countries.
Adrian I CamposGenetic Epidemiology Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Paul M ThompsonImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, California.
Dick J VeltmanAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Elena PozziDepartment of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Victoria, Australia; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.
Laura S van VeltzenDepartment of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Victoria, Australia; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.
Neda JahanshadImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, California.
Mark J AdamsDivision of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
Bernhard T BauneDepartment of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia; Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, North Rhine-Westphalia, Germany.
Katharina BroschDepartment of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Robin BülowInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany.
Colm G ConnollyDepartment of Biomedical Sciences, Florida State University, Tallahassee, Florida.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Christopher G DaveyDepartment of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Victoria, Australia.
Greig I de ZubicarayInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Danai DimaDepartment of Psychology, School of Arts and Social Sciences, City, University of London, London, United Kingdom; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Tracy Erwin-GrabnerLaboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Göttingen, Lower Saxony, Germany.
Jennifer W EvansExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Cynthia H Y FuCentre for Affective Disorders, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, United Kingdom; School of Psychology, University of East London, London, United Kingdom.
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, California.
Roberto Goya-MaldonadoLaboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Göttingen, Lower Saxony, Germany.
Hans J GrabeGerman Center for Neurodegenerative Disease, Greifswald, Mecklenburg-Vorpommern, Germany.
Dominik GrotegerdDepartment of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Matthew A HarrisDivision of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
Ben J HarrisonDepartment of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Victoria, Australia.
Sean N HattonBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Marco HermesdorfInstitute of Epidemiology and Social Medicine, University of Münster, Münster, North Rhine-Westphalia, Germany.
Ian B HickieBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Tiffany C HoDepartment of Psychiatry & Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California.
Tilo KircherDepartment of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Axel KrugDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, North Rhine-Westphalia, Germany; Department of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Jim LagopoulosThompson Institute, University of the Sunshine Coast, Sunshine Coast, Queensland, Australia; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Hannah LemkeDepartment of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Katie McMahonHerston Imaging Research Facility & School of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Frank P MacMasterDepartment of Pediatrics and Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Strategic Clinical Network for Addictions and Mental Health, Alberta Health Services, Calgary, Alberta, Canada.
Nicholas G MartinGenetic Epidemiology Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
Sarah E MedlandFaculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Psychiatric Genetics Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Austalia; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia.
Susanne MeinertDepartment of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Tina MellerDepartment of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Igor NenadicDepartment of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Nils OpelDepartment of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Ronny RedlichDepartment of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Liesbeth RenemanDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands.
Jonathan ReppleDepartment of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Matthew D SacchetCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
Simon SchmittDepartment of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Anouk SchranteeDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands.
Kang SimWest Region, Institute of Mental Health, Buangkok View, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Aditya SinghLaboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Göttingen, Lower Saxony, Germany.
Frederike SteinDepartment of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Lachlan T StrikeQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Nic J A van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands.
Steven J A van der WerffDepartment of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany.
Lena WaltemateDepartment of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Heather C WhalleyDivision of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
Katharina WittfeldGerman Center for Neurodegenerative Disease, Greifswald, Mecklenburg-Vorpommern, Germany.
Margaret J WrightQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia.
Tony T YangDepartment of Psychiatry & Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California.
Carlos A ZarateExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Lianne SchmaalOrygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia. Electronic address: lianne.schmaal@unimelb.edu.au.
Miguel E RenteríaGenetic Epidemiology Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. Electronic address: miguel.renteria@qimrberghofer.edu.au.
ENIGMA-MDD Working Group
University of Münster · DEPhilipps University of Marburg · DEThe University of Melbourne · AUThe University of Queensland · AUUniversity of Edinburgh · GBThe University of Sydney · AUUniversitätsmedizin Göttingen · DEAmsterdam University Medical Centers · NLGerman Center for Neurodegenerative Diseases · DELeiden University · NLNational Institutes of Health · USQueensland University of Technology · AUUniversitätsmedizin Greifswald · DEUniversity of California, San Francisco · USUniversity of Southern California · USAlberta Health Services · CAAmsterdam Neuroscience · NLCity, University of London · GBFlorida State University · USHarvard University · US
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MPsychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6MA Cross-Sectional and Longitudinal Functional MRI Study of Adolescent DepressionR01MH085734 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YANG, TONY TUNG-I · 2010 to 2014
$2.7MGenetic influences on the brain: A twin imaging studyR01HD050735 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI WRIGHT, MARGARET JANE · 2007 to 2011
$2.6MA global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA ConsortiumR01MH117601 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, SCHMAAL, LIANNE · 2018 to 2021
$1.5MThe Roles of Inflammatory and Glutamatergic Processes in the Neurodevelopmental Mechanisms Underlying Adolescent DepressionK01MH117442 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, TIFFANY CHEING · 2018 to 2022
$881kNeural mechanisms of meditation training in healthy and depressed adolescents: An MRI connectome studyR61AT009864 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TYMOFIYEVA, OLGA, YANG, TONY TUNG-I · 2019 to 2020
$822kMedical Research Council G0802594Medical Research Council MC_PC_17209NCCIH NIH HHS R61 AT009864NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD050735NIMH NIH HHS K01 MH117442NIMH NIH HHS R01 MH085734NIMH NIH HHS R01 MH117601NIMH NIH HHS R37 MH101495Wellcome TrustWellcome Trust 104036/Z/14/Z
Abstract
backgroundNeuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior.
methodsHere, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects.
resultsWe identified 25 regions of interest with statistically significant (false discovery rate < .05) differences between groups. Post hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum and lower surface area of the left inferior parietal lobe.
conclusionsThis study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviors may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.
Indexed as
Major Depressive DisorderSuicide, AttemptedBrainHumansMagnetic Resonance ImagingNeuroimagingMajor depressive disorderStructural magnetic resonance imagingSuicide attempt
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