ArticleArchives of public health = Archives belges de sante publique2021
Blood lead and cadmium levels are negatively associated with bone mineral density in young female adults.
Article in Archives of public health = Archives belges de sante publique, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Association between blood lead levels and body composition parameters in middle-aged pre- and postmenopausal women.BMC public health · 2026Article
- Sex differences in association of mixed exposure to blood cadmium, lead, mercury, selenium, manganese with osteoporosis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Catechin hydrate prevents cadmium-induced collagen downregulation in mesenchymal stem cellsResearch in pharmaceutical sciences · 2025Article
- Impact of Maternal Exposure to Trace Metal Mixtures on Bone Mineral Density in Children Aged 3-6: Results from the Guangxi Zhuang Birth Cohort, China.Biological trace element research · 2025Article
- Women's bone health trajectories from pregnancy to postpartum: Associations with bone-seeking metal exposure mixtures during pregnancy.Ecotoxicology and environmental safety · 2025Article
- Metal(oid) profiling of the common site of osteoporotic fractures with bone microarchitecture correlation analysis: a comparative study of hip fracture patients and healthy individuals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Lead poisoning and its effects on bone density.Scientific reports · 2025Article
- Analysis of the association between mixed exposure to multiple metals and comorbidity of osteopenia or osteoporosis: baseline data from the Chinese Multi-Ethnic Cohort study (CMEC).BMC public health · 2025Article
- The influence of adult urine lead exposure on bone mineral densit: NHANES 2015-2018.Frontiers in endocrinology · 2024Article
- Association of per- and polyfluoroalkylated substances/heavy metals and bone health in children and adolescents.Frontiers in public health · 2024Article
- Race and Gender Differences in the Associations Between Cadmium Exposure and Bone Mineral Density in US Adults.Biological trace element research · 2023Article
- Associations between cadmium exposure and whole-body aging: mediation analysis in the NHANES.BMC public health · 2023Article
- Relationship of blood heavy metals and osteoporosis among the middle-aged and elderly adults: A secondary analysis from NHANES 2013 to 2014 and 2017 to 2018.Frontiers in public health · 2023Article
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- The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999-2006 and 2011-2018.Nutrients · 2022Article
- Association between parity and bone mineral density in postmenopausal women.BMC women's health · 2022Article
- Association between Serum Cotinine Levels and Bone Mineral Density: An Analysis of the National Health and Nutrition Examination Survey (NHANES).International journal of endocrinology · 2022Article
- Blood Lead Level Is Negatively Associated With Bone Mineral Density in U.S. Children and Adolescents Aged 8-19 Years.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe organ toxicities of lead and cadmium have been extensively studied; however, studies of their toxic effects on bone remain limited, especially in young adults. The objective of this study was to examine the associations of blood lead levels (BLL) and blood cadmium levels (BCL) with bone mineral density (BMD) among young adults.
methodsWe performed a cross-sectional study using the National Health and Nutrition Examination Survey 2011-2018 database. Because of the skewed distribution, BLL and BCL were Ln-transformed for analysis. Weighted multivariate regressions were performed to evaluate the associations between LnBLL and LnBCL and lumbar BMD. Subgroup analyses were further performed.
resultsA total of 3234 participants aged 20-35 years were included in this study. No significant association between LnBLL and lumbar BMD was found (β = - 5.6, 95%CI: - 13.5-2.3). However, in the subgroup analysis stratified by sex, this association became negative in women (β = - 18.2, 95%CI: - 29.9- - 6.4). Moreover, this negative association was more prominent in female blacks (β = - 35.5, 95%CI: - 63.4- - 7.6). On the other hand, a negative association between LnBCL and lumbar BMD was found (β = - 7.4, 95%CI: - 14.0- - 0.8). In the subgroup analysis stratified by sex, this negative association only existed in women (β = - 18.7, 95%CI: - 28.0- - 9.5). Moreover, this negative association was more prominent in female whites (β = - 31.1, 95%CI: - 46.2- - 16.1).
conclusionsOur finding showed that both BLL and BCL were independently and negatively associated with lumbar BMD among young females, but not among young males.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.