Evidence map›Paper›PMID 34172057›Full record

SynthesisJournal of orthopaedic surgery and research2021

A comparison of thrombosis in total knee arthroplasty with and without a tourniquet: a meta-analysis of randomized controlled trials.

Jia Xie, Hao Yu, Fangyuan Wang, Juehua Jing, Jun Li

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Non-tourniquet strategy with high-position low-perfusion in distal humeral fracture surgery: reduces swelling without increasing blood loss.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
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  20. Perioperative Deep Vein Thrombosis in Elderly Patients with Lower Extremity Fracture: A Comprehensive Review of Anesthetic Management Strategies.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jia Xie *Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China.
Hao Yu *Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China.
Fangyuan WangDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China.
Juehua JingDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China.
Jun LiDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China. efylijunpaper@163.com.ORCID http://orcid.org/0000-0001-6383-6065
Anhui Medical University · CN

Funding

Basic and Clinical Cooperative Research Promotion Plan of Anhui Medical University 2020xkjT040Clinical Research cultivation Program of the Second Affiliated Hospital of Anhui Medical University 2020LCZD20Key Research and Development project of Anhui Province 201904b11020032National Natural Science Foundation of China Youth Program 81702656
6 · The paper itself

Abstract

backgroundTourniquets are widely used in total knee arthroplasty (TKA), but the issue of their safety remains controversial. Previous studies have focused on TKA blood loss, duration of surgery, and hemostatic drugs. The purpose of this meta-analysis was to analyze the effect of tourniquet use on postoperative deep venous thrombosis (DVT).

methodsPubMed, SCOPUS, Web of Science, Embase, and the Cochrane Library were searched for randomized clinical trials published before April 17, 2020, that compared the effect of tourniquet use on postoperative DVT, knee circumference, D-dimers, and pain measured using the visual analog scale (VAS).

resultsFourteen clinical trials that included 1321 unique participants were included in the meta-analysis. Among the total, 721 and 600 participants were randomized to the tourniquet and non-tourniquet groups, respectively. The incidence of postoperative thrombosis in the tourniquet group was significantly higher than in the non-tourniquet group (RR 2.30, 95% CI 1.51-3.49, P < 0.0001, I

conclusionResults of this meta-analysis indicate that tourniquet application could increase the incidence of postoperative DVT and aggravate postoperative pain and swelling in the short term. LEVEL OF EVIDENCE: Level III.

Indexed as

AgedArthroplasty, Replacement, KneeBlood Loss, SurgicalFemaleFibrin Fibrinogen Degradation ProductsHumansIncidenceKneeMaleMiddle AgedPain MeasurementPostoperative ComplicationsPostoperative PainRandomized Controlled Trials as TopicTourniquetsTreatment OutcomeFibrin Fibrinogen Degradation Productsfibrin fragment DComplicationMeta-analysisThrombosisTotal knee arthroplastyTourniquet

Identifiers

PMID34172057
PMCPMC8228914
OpenAlexW3133994158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.