ArticleBMC public health2021
Prevalence of diabetes and hypertension and their interaction effects on cardio-cerebrovascular diseases: a cross-sectional study.
Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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56 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Meta-analysis of Early Risk Factors Associated with Cerebrovascular Diseases.Current neurovascular research · 2026Pooled it
- Results From a Randomized, Open-Label, Crossover Study Evaluating the Effect of the Aldosterone Synthase Inhibitor Baxdrostat on the Pharmacokinetics of Metformin in Healthy Human Subjects.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023 · on this mapTrial
- Relations of Life's Essential 8 score with arterial and microvascular function: The Jackson Heart Study.Vascular medicine (London, England) · 2026Article
- Adherence to the DASH Diet in the Spanish Population and Its Environmental Impact: An Ecological Study.Nutrients · 2026Article
- Consensus on the management of hypertension in individuals with diabetes by Asian-Pacific Society of hypertension (APSH) & Diabetes Asia Study Group (DASG).Journal of human hypertension · 2026Article
- Prevalence of diabetes/prediabetes and their associated risk factors among adults with hypertension from iran: a nationwide study.Scientific reports · 2026Article
- Clinical characteristics of extremely elderly versus normal elderly patients with chronic limb-threatening ischemia: a single-center real-event retrospective study.European journal of medical research · 2025Article
- Prevalence and associated factors of co-occurring diabetes and hypertension among university academic staff and students in Bangladesh.Scientific reports · 2025Article
- Frailty transitions and risk of chronic kidney disease: insights from the China Health and Retirement Longitudinal Study.Renal failure · 2025Article
- From guidelines to practice: an Egyptian expert opinion on type 2 diabetes mellitus management in primary care settings.BMC primary care · 2025Article
- Development and validation of a nomogram prediction model for coronary heart disease in diabetic patients: a study based on the 2011-2020 NHANES database.BMC cardiovascular disorders · 2025Article
- The Impact of Diabetes on Exercise Tolerance in Patients After Cardiovascular Events.Journal of clinical medicine · 2025Article
- The major risk factor of stroke across Indonesia; a nationwide geospatial analysis of universal health coverage program.Archives of public health = Archives belges de sante publique · 2025Article
- Association of tooth brushing behavior with risks of major chronic health outcomes: a scoping review.BMC oral health · 2025Article
- Unveiling the twin epidemics of hypertension and diabetes: a cross-sectional analysis of sex-specific prevalence, risk, and hotspots in India's epidemiological transition zones.BMC public health · 2025Article
- Factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control study.BMC neurology · 2025Article
- Article
- Construction of a predictive model for type 2 diabetes mellitus with coexisting hypertension: A cross-sectional study.Medicine · 2025Observational
- Factors associated with hypertension among patients with type 2 diabetes: evidence from a resource-limited setting-Southern Ethiopia.Frontiers in endocrinology · 2025Article
- Examining shift duration and sociodemographic influences on the well-being of healthcare professionals in the United Arab Emirates: a cross-sectional study.Frontiers in public health · 2025Article
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3 authors at 2 institutions in 1 country.
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Abstract
backgroundHypertension and diabetes mellitus are two of the major risk factors for cardio-cerebrovascular diseases (CVDs). Although prior studies have confirmed that the coexistence of the two can markedly increase the risk of CVDs, few studies investigated whether potential interaction effects of hypertension and diabetes can result in greater cardio-cerebrovascular damage. We aimed to investigate the prevalence of hypertension and diabetes and whether they both affect synergistically the risk of CVDs.
methodsA cross-sectional study was conducted by using a multistage stratified random sampling among communities in Changsha City, Hunan Province. Study participants aged > = 18 years were asked to complete questionnaires and physical examinations. Multivariate logistic regression models were performed to evaluate the association of diabetes, hypertension, and their multiplicative interaction with CVDs with adjustment for potential confounders. We also evaluated additive interaction with the relative excess risk ratio (RERI), attribution percentage (AP), synergy index (SI).
resultsA total of 14,422 participants aged 18-98 years were collected (men = 5827, 40.7%). The prevalence was 22.7% for hypertension, 7.0% for diabetes, and 3.8% for diabetes with hypertension complication, respectively. Older age, women, higher educational level, unmarried status, obesity (central obesity) were associated with increased risk of hypertension and diabetes. We did not find significant multiplicative interaction of diabetes and hypertension on CVDs, but observed a synergistic additive interaction on coronary heart disease (SI, 1.43; 95% CI, 1.03-1.97; RERI, 1.94; 95% CI, 0.05-3.83; AP, 0.26; 95% CI, 0.06-0.46).
conclusionsDiabetes and hypertension were found to be associated with a significantly increased risk of CVDs and a significant synergistic additive interaction of diabetes and hypertension on coronary heart disease was observed. Participants who were old, women, highly educated, unmarried, obese (central obese) had increased risk of diabetes and hypertension.
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