Evidence map›Paper›PMID 34172024›Full record

ArticleBMC pregnancy and childbirth2021

Should singleton birth weight standards be applied to identify small-for-gestational age twins?: analysis of a retrospective cohort study.

Dongxin Lin, Jiaming Rao, Dazhi Fan, Zheng Huang, Zixing Zhou, Gengdong Chen, Pengsheng Li, Xiafen Lu, Demei Lu, Huishan Zhang and 3 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Adverse neonatal outcomes in small-for-gestational age twins identified using twin vs singleton growth charts: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Pooled it
  3. Accuracy of ultrasound estimation of fetal weight in twin pregnancy.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  4. Inter-twin growth discordance in monochorionic twins as a novel risk factor for preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Dongxin LinFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China.
Jiaming RaoFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China.
Dazhi FanFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China.
Zheng HuangThe First Affiliated Hospital of Guangdong Pharmaceutical University, 510030, Guangzhou, Guangdong, China.
Zixing ZhouFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China.
Gengdong ChenFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China.
Pengsheng LiFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China.
Xiafen LuDepartment of Obstetrics, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 528000, Foshan, Guangdong, China.
Demei LuFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China.
Huishan ZhangFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China.
Caihong LuoDepartment of Obstetrics, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 528000, Foshan, Guangdong, China.
Xiaoling GuoFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China.
Zhengping LiuFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China. liuzphlk81@outlook.com.
Southern Medical University · CNFoshan Maternity and Child Health Care Hospital · CNFirst Affiliated Hospital of Guangdong Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTwin birth weight percentiles are less popular in clinical management among twin pregnancies compared with singleton ones in China. This study aimed to compare the incidence and neonatal outcomes of small for gestational age (SGA) twins between the use of singleton and twin birth weight percentiles.

methodsThis was a retrospective cohort study of 3,027 pregnancies with liveborn twin pairs at gestational age of > 28 weeks. The newborns were categorized as SGA when a birthweight was less than the 10th percentile based on the singleton and twin references derived from Chinese population. Logistic regression models with generalized estimated equation (GEE) were utilized to evaluate the association between SGA twins and neonatal outcomes including neonatal unit admission, neonatal jaundice, neonatal respiratory distress (NRDS), neonatal asphyxia, ventilator support, hypoxic ischemic encephalopathy (HIE), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intracranial hemorrhage (ICH), culture-proven sepsis, neonatal death within 28 days after birth as well as the composite outcome.

resultsThe incidence of SGA was 33.1 % based on the singleton reference and 7.3 % based on the twin reference. Both of SGA newborns defined by the singleton and twin references were associated with increases in neonatal unit admission, neonatal jaundice and ventilator support. In addition, SGA newborns defined by the twin reference were associated with increased rates of BPD (aOR, 2.61; 95 % CI: 1.18-5.78) as well as the severe composite outcome (aOR, 1.93; 95 % CI: 1.07-3.47).

conclusionsThe use of singleton birth weight percentiles may result in misdiagnosed SGA newborns in twin gestations and the twin birth weight percentiles would be more useful to identify those who are at risk of adverse outcomes.

Indexed as

Birth WeightInfant, Small for Gestational AgeChinaDiseases in TwinsFemaleGestational AgeHumansIncidenceInfant, NewbornInfant, Newborn, DiseasesLogistic ModelsMalePregnancyPregnancy, TwinReference StandardsRetrospective StudiesBirth weight percentilesNeonatal outcomesSmall for gestational ageTwins

Identifiers

PMID34172024
PMCPMC8234673
OpenAlexW3175772201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.