Evidence map›Paper›PMID 34172004›Full record

ArticleBMC infectious diseases2021

Operational characteristics of an antibody detecting point of care test for Taenia solium infections in a community and hospital setting.

Chishimba Mubanga, Kabemba E Mwape, Isaac K Phiri, Chiara Trevisan, Mwemezi Kabululu, Gideon Zulu, Inge Van Damme, Veronika Schmidt, Pierre Dorny, Sarah Gabriël

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Chishimba MubangaDepartment of Clinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia. chishimbamubanga@yahoo.com.
Kabemba E MwapeDepartment of Clinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia.
Isaac K PhiriDepartment of Clinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia.
Chiara TrevisanDepartment of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Mwemezi KabululuTanzania Livestock Research Institute (TALIRI) - Uyole, P. O. Box 6191, Mbeya, Tanzania.
Gideon ZuluProvincial Health Office, Ministry of Health, Chipata, Zambia.
Inge Van DammeDepartment of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Veronika SchmidtDepartment of Neurology, Centre for Global Health, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.
Pierre DornyDepartment of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Sarah GabriëlDepartment of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
University of Zambia · ZMGhent University · BEInstituut voor Tropische Geneeskunde · BEMinistry of Health · ZMTanzania Wildlife Research Institute · TZUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiagnostic test evaluation includes measures of performance and assessment of operational characteristics. The latter focuses on end-user understanding of instructions to perform the test, ease of use, test turnaround time and ease of result interpretation. This study aimed to assess user comprehension of training for and ease of use of a Taenia solium point of care test (TS POC) evaluated in a community and hospital setting in Zambia and Tanzania, respectively.

methodsThe TS POC is a three-step in-house-produced rapid diagnostic test (RDT) for the simultaneous detection of taeniosis (TST) and cysticercosis (TSCC) antibodies. Data collected by administering questionnaires to 29 end-users and from the main evaluation database was analyzed quantitatively.

resultsEnd-users (28/29, 97%) perceived that the training they received for performing the test was sufficient. They performed 4080 tests, of which 80 were invalid. The community-based study and TST tests had higher invalid rates. The overall result interpretation was within the acceptable range of RDTs with an overall disagreement between readers of 3.3%. The Kappa coefficient of agreement was 85 and 82% for TSCC and TST, respectively. There was more disagreement among readers in the community-based study.

conclusionEnd-users rated the TS POC kit moderate in terms of ease of use citing long test turnaround time and difficulties in using the blood transfer device. Overall, the operational performance of the TS POC kit and end-users was within the established acceptable performance range.

Indexed as

Point-of-Care TestingTaenia soliumAdultAnimalsAntibodies, HelminthCommunity Health ServicesCysticercosisFemaleHospitalsHumansMaleMiddle AgedTaeniasisTanzaniaYoung AdultZambiaAntibodies, Helminth

Identifiers

PMID34172004
PMCPMC8235832
OpenAlexW3176969308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.