Evidence map›Paper›PMID 34171734›Full record

ArticleBiosensors & bioelectronics2021

3D fuzzy graphene microelectrode array for dopamine sensing at sub-cellular spatial resolution.

Elisa Castagnola, Raghav Garg, Sahil K Rastogi, Tzahi Cohen-Karni, Xinyan Tracy Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
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  11. Article
  12. Surface-Roughened Graphene Oxide Microfibers Enhance Electrochemical Reversibility.Langmuir : the ACS journal of surfaces and colloids · 2024
    Article
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  14. Review
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  17. Graphene-based cardiac sensors and actuators.Frontiers in bioengineering and biotechnology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elisa CastagnolaDepartment of Bioengineering, University of Pittsburgh, 3501 Fifth Ave. Pittsburgh, PA 15260 Pittsburgh, PA, USA.
Raghav GargDepartment of Materials Science and Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA, 15213, USA.
Sahil K RastogiDepartment of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA, 15213, USA.
Tzahi Cohen-KarniDepartment of Materials Science and Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA, 15213, USA; Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA, 15213, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive Pittsburgh, PA, 15219-3110, USA. Electronic address: tzahi@andrew.cmu.edu.
Xinyan Tracy CuiDepartment of Bioengineering, University of Pittsburgh, 3501 Fifth Ave. Pittsburgh, PA 15260 Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive Pittsburgh, PA, 15219-3110, USA; Center for Neural Basis of Cognition, University of Pittsburgh, 4400 Fifth Ave, Pittsburgh, PA 15213, Pittsburgh, PA, 15261, USA. Electronic address: xic11@pitt.edu.

Funding

Improving chronic neural recording performance through biomaterial strategiesR01NS062019 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2008 to 2018
$4.4M
Efficiency and Safety of Microstimulation Via Different Electrode MaterialsR01NS110564 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2019 to 2024
$3.1M
Inhibition of Neural Electrode-mediated Inflammation and Neuronal Cell DeathR01NS089688 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2015 to 2019
$3.1M
Ultra sensitive and flexible MEAs for chronic dopamine detection at both tonic and phasic levelsR21DA049592 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2019 to 2020
$428k
Dual Polymer Coatings for High Fidelity and Stable In Vivo Cocaine Sensing From MEAsR21DA043817 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2017 to 2018
$421k
NIDA NIH HHS R21 DA043817NIDA NIH HHS R21 DA049592NINDS NIH HHS R01 NS062019NINDS NIH HHS R01 NS089688NINDS NIH HHS R01 NS110564
6 · The paper itself

Abstract

The development of a high sensitivity real-time sensor for multi-site detection of dopamine (DA) with high spatial and temporal resolution is of fundamental importance to study the complex spatial and temporal pattern of DA dynamics in the brain, thus improving the understanding and treatments of neurological and neuropsychiatric disorders. In response to this need, here we present high surface area out-of-plane grown three-dimensional (3D) fuzzy graphene (3DFG) microelectrode arrays (MEAs) for highly selective, sensitive, and stable DA electrochemical sensing. 3DFG microelectrodes present a remarkable sensitivity to DA (2.12 ± 0.05 nA/nM, with LOD of 364.44 ± 8.65 pM), the highest reported for nanocarbon MEAs using Fast Scan Cyclic Voltammetry (FSCV). The high surface area of 3DFG allows for miniaturization of electrode down to 2 × 2 μm

Indexed as

Biosensing TechniquesGraphiteDopamineElectrochemical TechniquesHumansMicroelectrodesDopamineGraphite3D grapheneDopamineElectrochemical sensingFast scan cyclic voltammetryMicroelectrode arrays (MEAs)

Identifiers

PMID34171734
PMCPMC8376786

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.