Evidence map›Paper›PMID 34171656›Full record

ArticleEuropean journal of medicinal chemistry2021

Synthesis and evaluation of adenosine derivatives as A

Katarzyna Bednarska-Szczepaniak, Adam Mieczkowski, Aleksandra Kierozalska, Dijana Pavlović Saftić, Konrad Głąbała, Tomasz Przygodzki, Lidia Stańczyk, Kamil Karolczak, Cezary Watała, Harsha Rao and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Synthesis of Adenine Nucleosides with a Reactive (Molecules (Basel, Switzerland) · 2025
    Article
  4. Article
  5. APharmaceuticals (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Katarzyna Bednarska-SzczepaniakLaboratory of Medicinal Chemistry, Institute of Medical Biology PAS, Lodowa 106, 92-232, Łódź, Poland.
Adam MieczkowskiLaboratory of Biological Chemistry of Metal Ions, Institute of Biochemistry and Biophysics PAS, Pawińskiego 5a, 02-106, Warsaw, Poland.
Aleksandra KierozalskaLaboratory of Medicinal Chemistry, Institute of Medical Biology PAS, Lodowa 106, 92-232, Łódź, Poland.
Dijana Pavlović SaftićLaboratory of Medicinal Chemistry, Institute of Medical Biology PAS, Lodowa 106, 92-232, Łódź, Poland.
Konrad GłąbałaLaboratory of Medicinal Chemistry, Institute of Medical Biology PAS, Lodowa 106, 92-232, Łódź, Poland.
Tomasz PrzygodzkiDepartment of Haemostatic Disorders, Medical University of Lodz, 6/8 Mazowiecka St. 92-215, Lodz, Poland.
Lidia StańczykDepartment of Haemostatic Disorders, Medical University of Lodz, 6/8 Mazowiecka St. 92-215, Lodz, Poland.
Kamil KarolczakDepartment of Haemostatic Disorders, Medical University of Lodz, 6/8 Mazowiecka St. 92-215, Lodz, Poland.
Cezary WatałaDepartment of Haemostatic Disorders, Medical University of Lodz, 6/8 Mazowiecka St. 92-215, Lodz, Poland.
Harsha RaoLaboratory of Bioorganic Chemistry and Molecular Recognition Section, National Institute of Diabetes & Digestive & Kidney Diseases, NIH, Bethesda, MD, 20892-0810, USA.
Zhan-Guo GaoLaboratory of Bioorganic Chemistry and Molecular Recognition Section, National Institute of Diabetes & Digestive & Kidney Diseases, NIH, Bethesda, MD, 20892-0810, USA.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry and Molecular Recognition Section, National Institute of Diabetes & Digestive & Kidney Diseases, NIH, Bethesda, MD, 20892-0810, USA.
Zbigniew J LeśnikowskiLaboratory of Medicinal Chemistry, Institute of Medical Biology PAS, Lodowa 106, 92-232, Łódź, Poland. Electronic address: zlesnikowski@cbm.pan.pl.
Institute for Medical Biology · PLMedical University of Lodz · PLNational Institute of Diabetes and Digestive and Kidney Diseases · USInstitute of Biochemistry and Biophysics, Polish Academy of Sciences · PL

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Drugs that Act at Adenosine ReceptorsZ01DK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 1991 to 2008
$854k
Intramural NIH HHS Z01 DK031117Intramural NIH HHS ZIA DK031117
6 · The paper itself

Abstract

A series of adenosine and 2'-deoxyadenosine pairs modified with a 1,12-dicarba-closo-dodecaborane cluster or alternatively with a phenyl group at the same position was synthesized, and their affinity was determined at A

Indexed as

AdenosineAdenosine A3 Receptor AgonistsAnimalsBoron CompoundsCHO CellsCricetulusHEK293 CellsHumansLigandsMolecular StructurePlatelet Aggregation InhibitorsReceptor, Adenosine A3Structure-Activity RelationshipAdenosineAdenosine A3 Receptor AgonistsBoron CompoundsLigandsPlatelet Aggregation InhibitorsReceptor, Adenosine A3AdenosineAgonistsAntagonistsBoron clusterNucleosidesPurinergic receptorsSelectivity

Identifiers

PMID34171656
PMCPMC8448983
OpenAlexW3168315206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.