Observational studyJournal of vascular surgery. Venous and lymphatic disorders2022
The clinical significance of ultra-high D-dimer levels.
Observational study in Journal of vascular surgery. Venous and lymphatic disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of risk prediction model of venous thromboembolism for patients with lung cancer.Thoracic cancer · 2024Pooled it
- Trial
- Short- and long-term risk stratification in acutely ill medical patients by implementing D-dimer in the emergency setting - A prospective cohort study.American heart journal plus : cardiology research and practice · 2026Article
- From microbial dynamics to risk prediction: a nomogram-based model for hospital-acquired infections in rehabilitation settings.Frontiers in cellular and infection microbiology · 2026Article
- D-dimer drives immune dysregulation in COVID-19 via chemokine modulation and inflammatory signaling.Virus research · 2025Article
- Association between single-nucleotide polymorphism rs868875 of CLEC4M gene and clinical severity of COVID-19 in a Brazilian population.Immunogenetics · 2025Article
- Routine Laboratory Tests Predict 72-h Fatality in Patients With D-Dimer Levels ≥ 2 μg/mL: A Retrospective Cohort Study Comparing Statistical and Machine Learning Models.Journal of clinical laboratory analysis · 2025Article
- Prognostic value of baseline plasma D-dimer levels in sepsis: a prospective cohort study.Practical laboratory medicine · 2025Article
- Interpretable machine learning for predicting optimal surgical timing in polytrauma patients with TBI and fractures to reduce postoperative infection risk.Scientific reports · 2025Article
- Thrombin generation indices and Wells score predict pulmonary embolism in patients with acute exacerbation of chronic obstructive pulmonary disease.Clinics (Sao Paulo, Brazil) · 2025Article
- Review
- Modulatory role ofiScience · 2024Article
- A Nomogram Model to Predict Deep Vein Thrombosis Risk After Surgery in Patients with Hip Fractures.Indian journal of orthopaedics · 2024Article
- Clinical manifestations of active tuberculosis patients coinfected with severe acute respiratory syndrome coronavirus-2.Journal of clinical tuberculosis and other mycobacterial diseases · 2023Article
- The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review.Frontiers in bioscience (Landmark edition) · 2023Review
- D-dimer levels at the time of admission to hospital as a predictor of outcome in trauma patients: A prospective observational study.Saudi journal of anaesthesiaArticle
- Significance of D-Dimer Levels in the Evaluation of Postoperative Muscular Calf Vein Thrombosis: A Restricted Cubic Spline Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePlasma D-dimer levels >5000 ng/mL are encountered in a number of conditions other than venous thromboembolism (VTE). Recent studies have used plasma D-dimer levels as a prognostic indicator for coronavirus disease 2019 (COVID-19) infection. The implications of abnormal levels are less clear for patients diagnosed with COVID-19 with a baseline elevation in plasma D-dimer levels. In the present study, we reviewed the occurrence of plasma D-dimer levels >5000 ng/mL and investigated the clinical significance of this finding before the onset of the COVID-19 pandemic.
methodsInpatient records for a 4-year period were screened for laboratory results of plasma D-dimer levels >5000 ng/mL. The patient data were reviewed for the clinical identifiers commonly associated with elevated plasma D-dimer levels, including VTE, cancer, sepsis, pneumonia, other infection, bleeding, and trauma. The patients were then categorized into groups stratified by the plasma D-dimer level to allow for comparisons between the various clinical diagnoses.
resultsA total of 671 patients were included in the present study. VTE was the most common diagnosis for patients with a plasma D-dimer level >5000 ng/mL, followed by cancer and pneumonia. Multiple clinical diagnoses were present in 61% of the patients. No clear cause for the ultra-high plasma D-dimer level could be identified in 11.3% of the patients. Among the patients lacking a clinical diagnosis at discharge, mortality was 24% in the 5000- to 10,000-ng/mL group, 28.6% in the 10,000- to 15,000-ng/mL group, and 75% in the >15,000-ng/mL group.
conclusionsVTE, cancer, and pneumonia were frequently present when ultra-high plasma D-dimer levels were encountered, and mortality was high when the levels were >15,000 ng/mL. The results from our study from a pre-COVID-19 patient population suggest that ultra-high plasma D-dimer levels indicate the presence of severe underlying disease. This should be considered when using the plasma D-dimer level as a screening tool or prognostic indicator for COVID-19 infection.
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